I Dalainas1. 1. 492 General Military Hospital, Alexandroupolis, Greece. hdlns@freemail.gr
Abstract
BACKGROUND: Disseminated Intravascular Coagulation (DIC) is an acquired syndrome characterized by systemic intravascular activation of coagulation, leading to deposition of fibrin in the circulation, occurring in the course of severe diseases. OBJECTIVE: To review literature for articles that focus on the pathogenesis, diagnosis, and management of DIC. INFORMATION SOURCES: Selected articles from the Index Medicus data base. STATE OF THE ART: Recent studies have elucidate the pathogenic pathways that can trigger DIC. However, clinical and laboratory diagnosis of the syndrome remains difficult, as there is no single laboratory test, sensitive and specific enough, to allow a definitive diagnosis of DIC. Cornerstone for the treatment of DIC remains the optimal management of the underlying disorder. However, therapeutic interventions based on our present knowledge of the pathogenesis of DIC may be appropriate. CONCLUSION: Recent research on DIC, resulted in the development of diagnostic algorithms for the diagnosis of the syndrome and better supportive therapeutic strategies.
BACKGROUND: Disseminated Intravascular Coagulation (DIC) is an acquired syndrome characterized by systemic intravascular activation of coagulation, leading to deposition of fibrin in the circulation, occurring in the course of severe diseases. OBJECTIVE: To review literature for articles that focus on the pathogenesis, diagnosis, and management of DIC. INFORMATION SOURCES: Selected articles from the Index Medicus data base. STATE OF THE ART: Recent studies have elucidate the pathogenic pathways that can trigger DIC. However, clinical and laboratory diagnosis of the syndrome remains difficult, as there is no single laboratory test, sensitive and specific enough, to allow a definitive diagnosis of DIC. Cornerstone for the treatment of DIC remains the optimal management of the underlying disorder. However, therapeutic interventions based on our present knowledge of the pathogenesis of DIC may be appropriate. CONCLUSION: Recent research on DIC, resulted in the development of diagnostic algorithms for the diagnosis of the syndrome and better supportive therapeutic strategies.