Literature DB >> 18401845

Two new cytotoxic pregnane glycosides from Cynanchum auriculatum.

Youbin Li1, Jianfeng Zhang, Xiaojie Gu, Yunru Peng, Weihua Huang, Shihui Qian.   

Abstract

Two new pregnane glycosides, kidjoranin 3- O- alpha-diginopyranosyl-(1-->4)- beta-cymaropyranoside (1) and kidjoranin 3-O-beta-digitoxopyranoside (2), together with one known compound caudatin 3 -O-beta-cymaropyranoside (3), were isolated from the roots of Cynanchum auriculatum. Their structures were established on the basis of NMR analyses. Compounds 1 - 3 were tested for their in vitro inhibitory activity against the growth of human tumor cell lines SMMC-7721, HeLa and MCF7; all of them displayed marked cytotoxic activities against cells SMMC-7721 and HeLa with IC (50) values ranging from 8.6 microM to 58.5 microM, yet no activity against the cell line MCF7 was detected.

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Year:  2008        PMID： 18401845     DOI： 10.1055/s-2008-1074505

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  5 in total

1.  A C 21 -Steroidal Glycoside Isolated from the Roots of Cynanchum auriculatum Induces Cell Cycle Arrest and Apoptosis in Human Gastric Cancer SGC-7901 Cells.

Authors:  Yi-Qi Wang; Shui-Juan Zhang; Hong Lu; Bo Yang; Liang-Fei Ye; Ru-Song Zhang
Journal:  Evid Based Complement Alternat Med       Date:  2013-12-19       Impact factor: 2.629

Review 2.  Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects.

Authors:  Lu Wang; Fujie Cai; Wei Zhao; Jinli Tian; Degang Kong; Xiaohui Sun; Qing Liu; Yueru Chen; Ying An; Fulin Wang; Xue Liu; Yi Wu; Honglei Zhou
Journal:  Molecules       Date:  2021-11-23       Impact factor: 4.411

3.  Cytotoxic and apoptosis-inducing properties of a C21-steroidal glycoside isolated from the roots of Cynanchum auriculatum.

Authors:  Liang-Fei Ye; Yi-Qi Wang; Bo Yang; Ru-Song Zhang
Journal:  Oncol Lett       Date:  2013-02-07       Impact factor: 2.967

Review 4.  Ethnobotany, Phytochemistry and Pharmacological Effects of Plants in Genus Cynanchum Linn. (Asclepiadaceae).

Authors:  Lu Han; Xiuping Zhou; Mengmeng Yang; Li Zhou; Xinxin Deng; Shijie Wei; Wenping Wang; Zhizhong Wang; Xue Qiao; Changcai Bai
Journal:  Molecules       Date:  2018-05-16       Impact factor: 4.411

5.  Total C-21 steroidal glycosides, isolated from the root tuber of Cynanchum auriculatum Royle ex Wight, attenuate hydrogen peroxide-induced oxidative injury and inflammation in L02 cells.

Authors:  Zhenhui Wu; Yingyu Wang; Xian Meng; Xinjie Wang; Zhenlin Li; Shihui Qian; Yingjie Wei; Luan Shu; Yongfang Ding; Peijuan Wang; Yunru Peng
Journal:  Int J Mol Med       Date:  2018-09-25       Impact factor: 4.101
  5 in total

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