Rosana Scalco1, Melissa O Premaor, Pedro E Fröehlich, Tania W Furlanetto. 1. Post-graduation Program in Medicine: Medical Sciences, Federal University of Rio Grande do Sul and Serviço de Patologia Clínica do Hospital de Clínicas de Porto Alegre , Rua Ramiro Barcellos 2400, Porto Alegre, RS, 90035-003, Brazil. roscalco@yahoo.com.br
Abstract
OBJECTIVES: Hypovitaminosis D (HD) and secondary hyperparathyroidism (SHP) are common in elders, and many factors could contribute to them. The objectives of this study were to estimate the prevalence of HD, SHP, and its associated factors, in individuals living in nonprofit homes for elders in south Brazil. Design Cross-sectional study. METHODS: Serum 25-hydroxyvitamin D 25(OH)D, intact parathyroid hormone (PTH), total calcium, phosphorus, alkaline phosphatase, magnesium, creatinine, and albumin levels were measured in late spring, November, 2005. The presence of factors potentially related with HD and SHP-age, sex, weight, height, skin phototype, sun exposure, exercise, smoking, use of < or = 5 medications or diuretics or alcohol, and daily calcium ingestion. RESULTS: 102 subjects age 77.8 +/- 9.0 were included in the study. HD was found in 85.7% and SHP in 53% of the subjects. The estimated daily calcium ingestion was 720 mg. There was no association between serum 25(OH)D levels and any of the risk factors evaluated. Serum 25(OH)D levels were correlated with serum PTH (r = -0.358, P = 0.000), calcium (r = 0.306, P = 0.002), and albumin (r = 0.253, P = 0.011) levels. In univariate analysis, SHP was positively associated with age (P = 0.006), and female sex (0.007); and negatively associated with sunlight exposure (P = 0.020), GFR (P = 0.000), Ln25(OH)D (P = 0.002), and total serum calcium (P = 0.024). After multivariate model adjustment, age [OR 1.09 (CI 1.01-1.18); P = 0.024], Ln25(OH)D [OR 0.92 (CI 0.08-0.74); P = 0.013], GFR [OR 0.96 (CI 0.92-0.99); P = 0.013], and hydrochlorothiazide treatment [OR 7.63 (CI 1.67-34.9); P = 0.008] were independently associated with SHP. CONCLUSIONS: HD and SHP are highly prevalent in elders living in old-age homes. No associations were established between common risk factors and low serum levels of 25(OH)D levels; however, SHP was independently related with age, 25(OH)D, GFR, and hydrochlorothiazide use.
OBJECTIVES:Hypovitaminosis D (HD) and secondary hyperparathyroidism (SHP) are common in elders, and many factors could contribute to them. The objectives of this study were to estimate the prevalence of HD, SHP, and its associated factors, in individuals living in nonprofit homes for elders in south Brazil. Design Cross-sectional study. METHODS: Serum 25-hydroxyvitamin D 25(OH)D, intact parathyroid hormone (PTH), total calcium, phosphorus, alkaline phosphatase, magnesium, creatinine, and albumin levels were measured in late spring, November, 2005. The presence of factors potentially related with HD and SHP-age, sex, weight, height, skin phototype, sun exposure, exercise, smoking, use of < or = 5 medications or diuretics or alcohol, and daily calcium ingestion. RESULTS: 102 subjects age 77.8 +/- 9.0 were included in the study. HD was found in 85.7% and SHP in 53% of the subjects. The estimated daily calcium ingestion was 720 mg. There was no association between serum 25(OH)D levels and any of the risk factors evaluated. Serum 25(OH)D levels were correlated with serum PTH (r = -0.358, P = 0.000), calcium (r = 0.306, P = 0.002), and albumin (r = 0.253, P = 0.011) levels. In univariate analysis, SHP was positively associated with age (P = 0.006), and female sex (0.007); and negatively associated with sunlight exposure (P = 0.020), GFR (P = 0.000), Ln25(OH)D (P = 0.002), and total serum calcium (P = 0.024). After multivariate model adjustment, age [OR 1.09 (CI 1.01-1.18); P = 0.024], Ln25(OH)D [OR 0.92 (CI 0.08-0.74); P = 0.013], GFR [OR 0.96 (CI 0.92-0.99); P = 0.013], and hydrochlorothiazide treatment [OR 7.63 (CI 1.67-34.9); P = 0.008] were independently associated with SHP. CONCLUSIONS:HD and SHP are highly prevalent in elders living in old-age homes. No associations were established between common risk factors and low serum levels of 25(OH)D levels; however, SHP was independently related with age, 25(OH)D, GFR, and hydrochlorothiazide use.
Authors: Denise G von Mühlen; Gail A Greendale; Cedric F Garland; Lori Wan; Elizabeth Barrett-Connor Journal: Osteoporos Int Date: 2005-06-01 Impact factor: 4.507
Authors: Tom Nijenhuis; Volker Vallon; Annemiete W C M van der Kemp; Johannes Loffing; Joost G J Hoenderop; René J M Bindels Journal: J Clin Invest Date: 2005-05-12 Impact factor: 14.808
Authors: M S Stein; L Flicker; S C Scherer; L M Paton; M L O'Brien; S C Walton; P Chick; M Di Carlantonio; J D Zajac; J D Wark Journal: Clin Endocrinol (Oxf) Date: 2001-05 Impact factor: 3.478
Authors: Melita M Dvorak; Cyrille De Joussineau; D Howard Carter; Trairak Pisitkun; Mark A Knepper; Gerardo Gamba; Paul J Kemp; Daniela Riccardi Journal: J Am Soc Nephrol Date: 2007-07-26 Impact factor: 10.121
Authors: Nathalia Regina Sabatini Gandolfi; Jose Eduardo Corrente; Alberto De Vitta; Loraine Gollino; Gláucia Maria Ferreira da Silva Mazeto Journal: Qual Life Res Date: 2019-09-11 Impact factor: 4.147
Authors: João Soares Felício; Rafael Mendonça Luz; Franciane Trindade Cunha de Melo; Fabricio de Souza Resende; Alana Ferreira de Oliveira; Amanda Soares Peixoto; João Felício Abrahão Neto; Carolina Tavares Carvalho; Denisson Dias da Silva; Marcia Costa Dos Santos; Natércia Neves Marques de Queiroz; Manuela Nascimento de Lemos; Elizabeth Sumi Yamada; Karem Miléo Felício Journal: Front Endocrinol (Lausanne) Date: 2016-12-12 Impact factor: 5.555
Authors: João Soares Felício; Ana Carolina Contente Braga de Souza; Camila Cavalcante Koury; João Felício Abrahão Neto; Karem Barbosa Miléo; Flávia Marques Santos; Ana Regina Bastos Motta; Denisson Dias Silva; Thaís Pontes Arbage; Carolina Tavares Carvalho; Hana Andrade de Rider Brito; Elizabeth Sumi Yamada; Roberta Arnoldi Cobas; Alessandra Matheus; Lucianne Tannus; Catia Cristina Sousa Palma; Leticia Japiassu; João Regis Ivar Carneiro; Melanie Rodacki; Lenita Zajdenverg; Neuza Braga Campos de Araújo; Marilena de Menezes Cordeiro; Jorge Luiz Luescher; Renata Szundy Berardo; Marcia Nery; Catarina Cani; Maria do Carmo Arruda Marques; Luiz Eduardo Calliari; Renata Maria de Noronha; Thais Della Manna; Roberta Savoldelli; Fernanda Garcia Penha; Milton Cesar Foss; Maria Cristina Foss-Freitas; Antonio Carlos Pires; Fernando Cesar Robles; Carlos Antonio Negrato; Maria de Fatima Guedes; Sergio Atala Dib; Patricia Dualib; Saulo Cavalcanti da Silva; Janice Sepúlveda; Emerson Sampaio; Rosangela Roginski Rea; Ana Cristina Ravazzani de Almeida Faria; Balduino Tschiedel; Suzana Lavigne; Gustavo Adolfo Cardozo; Mirela Azevedo; Luis Henrique Canani; Alessandra Teixeira Zucatti; Marisa Helena Cesar Coral; Daniela Aline Pereira; Luiz Antonio de Araujo; Hermelinda Cordeiro Pedrosa; Monica Tolentino; Flaviene Alves Prado; Nelson Rassi; Leticia Bretones de Araujo; Reine Marie Chaves Fonseca; Alexis Dourado Guedes; Odelisa Silva de Mattos; Manuel Faria; Rossana Azulay; Adriana Costa E Forti; Cristina Figueiredo Sampaio Façanha; Renan Montenegro Junior; Ana Paula Montenegro; Naira Horta Melo; Karla Freire Rezende; Alberto Ramos; Deborah Laredo Jezini; Marilia Brito Gomes Journal: Diabetol Metab Syndr Date: 2015-10-06 Impact factor: 3.320
Authors: Kleyton de Carvalho Mesquita; Ana Carolina de Souza Machado Igreja; Izelda Maria Carvalho Costa Journal: An Bras Dermatol Date: 2013 Nov-Dec Impact factor: 1.896
Authors: Ana Carolina Contente Braga de Souza; João Soares Felício; Camila Cavalcante Koury; João Felício Abrahão Neto; Karem Barbosa Miléo; Flávia Marques Santos; Carlos Antonio Negrato; Ana Regina Bastos Motta; Denisson Dias Silva; Thaís Pontes Arbage; Carolina Tavares Carvalho; Hana Andrade de Rider Brito; Elizabeth Sumi Yamada; Franciane Trindade Cunha de Melo; Fabricio de Souza Resende; Juliana Cristina Cardoso Ferreira; Marilia Brito Gomes Journal: Health Qual Life Outcomes Date: 2015-12-24 Impact factor: 3.186