BACKGROUND AND OBJECTIVES: Although albumin excretion rates have been related to cardiovascular morbidity and mortality in both diabetic and nondiabetic adults, little is known about the relation between albuminuria and either cardiovascular risk factors or the insulin resistance syndrome in adolescents. A normal range for albumin excretion in adolescents was established, correlations between albumin excretion and cardiovascular risk factors were evaluated, and albumin excretion in normal adolescents was compared with that in type 1 diabetes mellitus adolescents. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Albumin excretion rate was measured in 368 normal and 175 diabetic adolescents. Multiple regression analysis was used to predict the relation of age, sex, Tanner stage, body mass index, and systolic blood pressure to albumin excretion in both cohorts. In addition, correlations between albumin excretion and age, blood pressure, body mass index, lipids, and measurements of insulin resistance were performed in the normal adolescents. RESULTS: Mean albumin excretion was significantly lower in normal adolescents (4.0 microg/min) than in type 1 diabetic adolescents (5.0 microg/min). Albumin excretion increased with age in diabetics. Albumin excretion did not significantly correlate with any measure of cardiovascular risk or insulin resistance but did significantly correlate with fasting insulin. CONCLUSIONS: Albumin excretion rate is not related to insulin resistance or traditional cardiovascular risk factors in adolescence but is related to fasting insulin. Diabetic adolescents have increased albumin excretion compared with normal adolescents.
BACKGROUND AND OBJECTIVES: Although albumin excretion rates have been related to cardiovascular morbidity and mortality in both diabetic and nondiabetic adults, little is known about the relation between albuminuria and either cardiovascular risk factors or the insulin resistance syndrome in adolescents. A normal range for albumin excretion in adolescents was established, correlations between albumin excretion and cardiovascular risk factors were evaluated, and albumin excretion in normal adolescents was compared with that in type 1 diabetes mellitus adolescents. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Albumin excretion rate was measured in 368 normal and 175 diabetic adolescents. Multiple regression analysis was used to predict the relation of age, sex, Tanner stage, body mass index, and systolic blood pressure to albumin excretion in both cohorts. In addition, correlations between albumin excretion and age, blood pressure, body mass index, lipids, and measurements of insulin resistance were performed in the normal adolescents. RESULTS: Mean albumin excretion was significantly lower in normal adolescents (4.0 microg/min) than in type 1 diabetic adolescents (5.0 microg/min). Albumin excretion increased with age in diabetics. Albumin excretion did not significantly correlate with any measure of cardiovascular risk or insulin resistance but did significantly correlate with fasting insulin. CONCLUSIONS: Albumin excretion rate is not related to insulin resistance or traditional cardiovascular risk factors in adolescence but is related to fasting insulin. Diabetic adolescents have increased albumin excretion compared with normal adolescents.
Authors: Hans L Hillege; Vaclav Fidler; Gilles F H Diercks; Wiek H van Gilst; Dick de Zeeuw; Dirk J van Veldhuisen; Rijk O B Gans; Wilbert M T Janssen; Diederick E Grobbee; Paul E de Jong Journal: Circulation Date: 2002-10-01 Impact factor: 29.690
Authors: Jacobien C Verhave; Hans L Hillege; Johannes G M Burgerhof; Gerjan Navis; Dick de Zeeuw; Paul E de Jong Journal: J Am Soc Nephrol Date: 2003-05 Impact factor: 10.121
Authors: M Roest; J D Banga; W M Janssen; D E Grobbee; J J Sixma; P E de Jong; D de Zeeuw; Y T van Der Schouw Journal: Circulation Date: 2001-06-26 Impact factor: 29.690
Authors: Frits A Wijburg; Bernard Bénichou; Daniel G Bichet; Lorne A Clarke; Gabriela Dostalova; Alejandro Fainboim; Andreas Fellgiebel; Cassiano Forcelini; Kristina An Haack; Robert J Hopkin; Michael Mauer; Behzad Najafian; C Ronald Scott; Suma P Shankar; Beth L Thurberg; Camilla Tøndel; Anna Tylki-Szymańska; Uma Ramaswami Journal: PLoS One Date: 2015-05-08 Impact factor: 3.240
Authors: Mark Daniels; Stephanie N DuBose; David M Maahs; Roy W Beck; Larry A Fox; Rose Gubitosi-Klug; Lori M Laffel; Kellee M Miller; Heather Speer; William V Tamborlane; Michael J Tansey Journal: Diabetes Care Date: 2013-04-22 Impact factor: 19.112