| Literature DB >> 18400499 |
Yun Oliver Long1, Robert I Higuchi, Thomas R Caferro, Thomas L S Lau, Min Wu, Marquis L Cummings, Esther A Martinborough, Keith B Marschke, William Y Chang, Francisco J López, Donald S Karanewsky, Lin Zhi.
Abstract
Modification on a lead series of [1,4]oxazino[3,2-g]quinolin-7-ones at the 2-position led to selective androgen receptor modulators with improved in vivo activity. The most potent analog (-)-33a exhibited full maintenance of levator ani muscle at 3mg/kg and reduced activity on ventral prostate weight in a 2-week orally-dosed and orchidectomized rat maintenance assay.Entities:
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Year: 2008 PMID： 18400499 DOI： 10.1016/j.bmcl.2008.03.062
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823