| Literature DB >> 18400497 |
Pierre Ducray1, Noëlle Gauvry, François Pautrat, Thomas Goebel, Joerg Fruechtel, Yves Desaules, Sandra Schorderet Weber, Jacques Bouvier, Trixie Wagner, Olivier Froelich, Ronald Kaminsky.
Abstract
A new series of amino-acetonitrile derivatives (AAD) have been discovered that exhibit high anthelmintic activity against parasitic nematode species such as Haemonchus contortus and Trichostrongylus colubriformis. Significantly, these compounds also demonstrate activity against nematode strains resistant to the currently available broad-spectrum anthelmintics. The discovery, synthesis, structure-activity relationship and biological results are presented.Entities:
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Year: 2008 PMID： 18400497 DOI： 10.1016/j.bmcl.2008.03.071
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823