Literature DB >> 18399201

Structural features of the Cu(II) complex with the rat Abeta(1-28) fragment.

Elena Gaggelli1, Zbigniew Grzonka, Henryk Kozłowski, Caterina Migliorini, Elena Molteni, Daniela Valensin, Gianni Valensin.   

Abstract

The interaction between Cu(II) and the rat amyloid beta (1-28) fragment in micellar solutions at pH 7.5 was investigated by CD and NMR spectroscopy; the proton-copper distances were used in restrained molecular dynamics simulations to obtain a structural model of the Cu(II) complex.

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Year:  2008        PMID： 18399201     DOI： 10.1039/b713453c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  Calorimetric investigation of copper(II) binding to Aβ peptides: thermodynamics of coordination plasticity.

Authors:  Cristina Sacco; Rachel A Skowronsky; Sunitha Gade; John M Kenney; Anne M Spuches
Journal:  J Biol Inorg Chem       Date:  2012-01-22       Impact factor: 3.358

2.  Combining conformational sampling and selection to identify the binding mode of zinc-bound amyloid peptides with bifunctional molecules.

Authors:  Liang Xu; Ke Gao; Chunyu Bao; Xicheng Wang
Journal:  J Comput Aided Mol Des       Date:  2012-07-25       Impact factor: 3.686

3.  Molecular-level examination of Cu2+ binding structure for amyloid fibrils of 40-residue Alzheimer's β by solid-state NMR spectroscopy.

Authors:  Sudhakar Parthasarathy; Fei Long; Yifat Miller; Yiling Xiao; Dan McElheny; Kent Thurber; Buyong Ma; Ruth Nussinov; Yoshitaka Ishii
Journal:  J Am Chem Soc       Date:  2011-02-22       Impact factor: 15.419

4.  Quantification of the binding properties of Cu2+ to the amyloid beta peptide: coordination spheres for human and rat peptides and implication on Cu2+-induced aggregation.

Authors:  Lian Hong; Tessa M Carducci; William D Bush; Christopher G Dudzik; Glenn L Millhauser; John D Simon
Journal:  J Phys Chem B       Date:  2010-09-02       Impact factor: 2.991

Review 5.  Polymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape.

Authors:  Yifat Miller; Buyong Ma; Ruth Nussinov
Journal:  Chem Rev       Date:  2010-08-11       Impact factor: 60.622

6.  The structure of the amyloid-beta peptide high-affinity copper II binding site in Alzheimer disease.

Authors:  Victor A Streltsov; Stephen J Titmuss; V Chandana Epa; Kevin J Barnham; Colin L Masters; Joseph N Varghese
Journal:  Biophys J       Date:  2008-07-03       Impact factor: 4.033

Review 7.  Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.

Authors:  Bruce X Wong; Ya Hui Hung; Ashley I Bush; James A Duce
Journal:  Front Aging Neurosci       Date:  2014-05-15       Impact factor: 5.750
  7 in total

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