Literature DB >> 18398717

Requirement of lipocalin 2 for chronic myeloid leukemia.

Ralph Arlinghaus1, Xiaohong Leng.   

Abstract

The Bcr-Abl oncoprotein causes chronic myeloid leukemia by a mechanism involving its activated tyrosine kinase. BCR-ABL+ mouse hematopoietic cells persistently express and secrete lipocalin 2 by a mechanism that requires the tyrosine kinase of the Bcr-Abl oncoprotein. Our new findings indicate that lipocalin 2 is required for leukemia induction, as prevention of expression of lipocalin 2 by BCR-ABL+ mouse marrow cells totally blocks leukemia induction in a mouse model.

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Year:  2008        PMID： 18398717     DOI： 10.1080/10428190701859664

Source DB:  PubMed          Journal:  Leuk Lymphoma        ISSN： 1026-8022


  8 in total

1.  The cancer marker neutrophil gelatinase-associated lipocalin is highly expressed in human endometrial hyperplasia.

Authors:  Chi-Jr Liao; Yen Hua Huang; Heng-Kien Au; Le-Ming Wang; Sin-Tak Chu
Journal:  Mol Biol Rep       Date:  2011-05-15       Impact factor: 2.316

Review 2.  The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer.

Authors:  Subhankar Chakraborty; Sukhwinder Kaur; Sushovan Guha; Surinder K Batra
Journal:  Biochim Biophys Acta       Date:  2012-03-31

3.  Inflammatory Responses of Astrocytes Are Independent from Lipocalin 2.

Authors:  Natalie Gasterich; Sophie Wetz; Stefan Tillmann; Lena Fein; Anke Seifert; Alexander Slowik; Ralf Weiskirchen; Adib Zendedel; Andreas Ludwig; Steffen Koschmieder; Cordian Beyer; Tim Clarner
Journal:  J Mol Neurosci       Date:  2020-09-21       Impact factor: 3.444

4.  Lipocalin 2 is required for pulmonary host defense against Klebsiella infection.

Authors:  Yvonne R Chan; Jessica S Liu; Derek A Pociask; Mingquan Zheng; Timothy A Mietzner; Thorsten Berger; Tak W Mak; Matthew C Clifton; Roland K Strong; Prabir Ray; Jay K Kolls
Journal:  J Immunol       Date:  2009-04-15       Impact factor: 5.422

Review 5.  Implication and role of neutrophil gelatinase-associated lipocalin in cancer: lipocalin-2 as a potential novel emerging comprehensive therapeutic target for a variety of cancer types.

Authors:  Sina Rahimi; Amaneh Mohammadi Roushandeh; Ebrahim Ahmadzadeh; Ali Jahanian-Najafabadi; Mehryar Habibi Roudkenar
Journal:  Mol Biol Rep       Date:  2020-01-22       Impact factor: 2.316

6.  Association of peripheral blood neutrophil gelatinase-associated lipocalin levels with bone marrow neutrophil gelatinase-associated lipocalin levels and neutrophil count in hematologic malignancy.

Authors:  Chi-Hyun Cho; Jung Yoon; Deok-Su Kim; Shin-Jong Kim; Hwa Jung Sung; Se Ryeon Lee
Journal:  J Clin Lab Anal       Date:  2019-05-15       Impact factor: 2.352

7.  Lipocalin 2 regulates inflammation during pulmonary mycobacterial infections.

Authors:  Lokesh Guglani; Radha Gopal; Javier Rangel-Moreno; Beth Fallert Junecko; Yinyao Lin; Thorsten Berger; Tak W Mak; John F Alcorn; Troy D Randall; Todd A Reinhart; Yvonne R Chan; Shabaana A Khader
Journal:  PLoS One       Date:  2012-11-20       Impact factor: 3.240

8.  Overexpression of lipocalin 2 in human cervical cancer enhances tumor invasion.

Authors:  I-Hsiao Chung; Tzu-I Wu; Chia-Jung Liao; Jin-Yo Hu; Yang-Hsiang Lin; Pei-Ju Tai; Chyong-Huey Lai; Kwang-Huei Lin
Journal:  Oncotarget       Date:  2016-03-08
  8 in total

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