PURPOSE: To investigate levels of proinflammatory cytokines in a mouse model of anterior ischemic optic neuropathy (rAION). METHODS: AION was induced in C57/BL6 mice and levels of IL-6, TNF-alpha, and MIP-2 were measured in plasma by ELISA and in the optic nerves by RT-PCR at predetermined intervals. RESULTS: Plasma: IL-6 levels were elevated immediately after rAION induction and decreased gradually thereafter. TNF-alpha showed an early peak on day 1 and again from day 21. MIP-2 levels were increased until day 7. Optic nerve: IL-6, TNF-alpha, and MIP-2 levels increased within a few hours and then decreased gradually. IL-6 had a second peak on day 3. CONCLUSIONS: Proinflammatory cytokines may play a role in the pathogenesis of rAION.
PURPOSE: To investigate levels of proinflammatory cytokines in a mouse model of anterior ischemic optic neuropathy (rAION). METHODS: AION was induced in C57/BL6 mice and levels of IL-6, TNF-alpha, and MIP-2 were measured in plasma by ELISA and in the optic nerves by RT-PCR at predetermined intervals. RESULTS: Plasma: IL-6 levels were elevated immediately after rAION induction and decreased gradually thereafter. TNF-alpha showed an early peak on day 1 and again from day 21. MIP-2 levels were increased until day 7. Optic nerve: IL-6, TNF-alpha, and MIP-2 levels increased within a few hours and then decreased gradually. IL-6 had a second peak on day 3. CONCLUSIONS: Proinflammatory cytokines may play a role in the pathogenesis of rAION.
Authors: Dimosthenis Mantopoulos; Peggy Bouzika; Athanassios Tsakris; Basil S Pawlyk; Michael A Sandberg; Joan W Miller; Joseph F Rizzo Iii; Demetrios G Vavvas; Dean M Cestari Journal: Curr Eye Res Date: 2016-05-09 Impact factor: 2.424
Authors: Louise A Mesentier-Louro; Laurel Stell; Yan Yan; Artis A Montague; Vinicio de Jesus Perez; Yaping Joyce Liao Journal: Transl Vis Sci Technol Date: 2021-07-01 Impact factor: 3.048