N Wang1, K Huang, H Zou, Y Shi, J Zhu, W Tang, X Xu. 1. Department of Ophthalmology, Shanghai Jiaotong University, Affiliated First People's Hospital, Shanghai, PR China.
Abstract
PURPOSE: Necrosis tumor factor (TNF) is known to be associated with diabetic retinopathy (DR). The objective of this study was to examine the genetic variations of TNF-alpha and assess their possible relationship to DR in type 2 diabetic patients in the Chinese population. MATERIALS AND METHODS: We conducted a case-control association study between the promoter variants of TNF-alpha and diabetic retinopathy in Chinese patients with type 2 diabetes. We selected three variants in the promoter region of TNF-alpha, namely rs1800629, rs1041981, and rs2857713. RESULTS: No individual SNP nor any haplotype was found to be associated with DR in our study. CONCLUSION: This is the first study to report TNF-alpha polymorphisms in patients with DR in the Chinese population. The results suggest that the variants among the promoter of TNF-alpha are unlikely to play a major role in the susceptibility to DR in Chinese patients with type 2 diabetes.
PURPOSE:Necrosis tumor factor (TNF) is known to be associated with diabetic retinopathy (DR). The objective of this study was to examine the genetic variations of TNF-alpha and assess their possible relationship to DR in type 2 diabeticpatients in the Chinese population. MATERIALS AND METHODS: We conducted a case-control association study between the promoter variants of TNF-alpha and diabetic retinopathy in Chinese patients with type 2 diabetes. We selected three variants in the promoter region of TNF-alpha, namely rs1800629, rs1041981, and rs2857713. RESULTS: No individual SNP nor any haplotype was found to be associated with DR in our study. CONCLUSION: This is the first study to report TNF-alpha polymorphisms in patients with DR in the Chinese population. The results suggest that the variants among the promoter of TNF-alpha are unlikely to play a major role in the susceptibility to DR in Chinese patients with type 2 diabetes.
Authors: K F Rodrigues; N T Pietrani; V C Sandrim; C M A F Vieira; A P Fernandes; A A Bosco; K B Gomes Journal: J Diabetes Res Date: 2015-05-06 Impact factor: 4.011