OBJECTIVE: To compare autonomic function, measured during handgrip (HG) and cold pressor (CP), between obese with and without type 2 diabetes and non-obese women in fasting and post-glucose load states. METHODS: Twelve obese women with type 2 diabetes (50 +/- 1 years), 15 obese women without type 2 diabetes (48 +/- 2 years), and 12 non-obese women (49 +/- 2 years) participated in this study. Heart rate variability (HRV) was determined during autonomic function tests, conducted in both the fasting state and after a glucose challenge (oral glucose tolerance test-OGTT). RESULTS: Obese women with and without diabetes and non-obese women responded similarly fasted and post-glucose challenge, such that in the fasted state low frequency power normalized (LF(nu)) to total power (TP), log transformed (Ln) low frequency to high frequency ratio (LnLF/HF) and heart rate (HR) significantly increased with the autonomic functional tasks (P < 0.05), whereas HF(nu) significantly decreased with the tasks (P < 0.05). Handgrip elicited a lower LnTP and a higher HR (P < 0.05) when compared to CP in the fasted state. In the glucose challenged state LF(nu), LnLF/HF and HR increased (P < 0.05) and HF(nu) significantly decreased (P < 0.05). INTERPRETATION: Results of autonomic testing did not differ between obese women, with and without diabetes, and non-obese women. The HG test elicited a greater reduction in HRV total power compared to the CP. This suggests that HG may be more useful when examining autonomic function in women with complicated diabetes.
OBJECTIVE: To compare autonomic function, measured during handgrip (HG) and cold pressor (CP), between obese with and without type 2 diabetes and non-obesewomen in fasting and post-glucose load states. METHODS: Twelve obesewomen with type 2 diabetes (50 +/- 1 years), 15 obesewomen without type 2 diabetes (48 +/- 2 years), and 12 non-obesewomen (49 +/- 2 years) participated in this study. Heart rate variability (HRV) was determined during autonomic function tests, conducted in both the fasting state and after a glucose challenge (oral glucose tolerance test-OGTT). RESULTS:Obesewomen with and without diabetes and non-obesewomen responded similarly fasted and post-glucose challenge, such that in the fasted state low frequency power normalized (LF(nu)) to total power (TP), log transformed (Ln) low frequency to high frequency ratio (LnLF/HF) and heart rate (HR) significantly increased with the autonomic functional tasks (P < 0.05), whereas HF(nu) significantly decreased with the tasks (P < 0.05). Handgrip elicited a lower LnTP and a higher HR (P < 0.05) when compared to CP in the fasted state. In the glucose challenged state LF(nu), LnLF/HF and HR increased (P < 0.05) and HF(nu) significantly decreased (P < 0.05). INTERPRETATION: Results of autonomic testing did not differ between obesewomen, with and without diabetes, and non-obesewomen. The HG test elicited a greater reduction in HRV total power compared to the CP. This suggests that HG may be more useful when examining autonomic function in women with complicated diabetes.
Authors: M Yamamoto; Y Yamasaki; M Kodama; M Matsuhisa; M Kishimoto; H Ozaki; A Tani; N Ueda; M Iwasaki; M Hori Journal: Diabetes Care Date: 1999-12 Impact factor: 19.112
Authors: H V Huikuri; J O Valkama; K E Airaksinen; T Seppänen; K M Kessler; J T Takkunen; R J Myerburg Journal: Circulation Date: 1993-04 Impact factor: 29.690
Authors: L A Ferrara; M Mancini; G D De Simone; S Turco; C Iovine; T Marotta; G Mainenti; M Mancini Journal: Int J Cardiol Date: 1991-09 Impact factor: 4.164
Authors: Jill A Kanaley; Styliani Goulopoulou; Ruth Franklin; Tracy Baynard; Robert L Carhart; Ruth S Weinstock; Bo Fernhall Journal: Metabolism Date: 2012-08-15 Impact factor: 8.694