Literature DB >> 18398535

Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes.

Sofia I Pascu1, Philip A Waghorn, Timothy D Conry, Bonita Lin, Helen M Betts, Jonathan R Dilworth, Robert B Sim, Grant C Churchill, Franklin I Aigbirhio, John E Warren.   

Abstract

We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.

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Year:  2008        PMID： 18398535     DOI： 10.1039/b802806k

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  6 in total

Review 1.  Mitochondrial metals as a potential therapeutic target in neurodegeneration.

Authors:  A Grubman; A R White; J R Liddell
Journal:  Br J Pharmacol       Date:  2014-04       Impact factor: 8.739

2.  Unravelling the antitumoral potential of novel bis(thiosemicarbazonato) Zn(II) complexes: structural and cellular studies.

Authors:  Elisa Palma; Hugo M Botelho; Goreti Ribeiro Morais; Inês Rodrigues; Isabel Cordeiro Santos; Maria Paula Cabral Campello; Paula Raposinho; Ana Belchior; Susana Sousa Gomes; Maria Fátima Araújo; Isabel Correia; Nadia Ribeiro; Sofia Gama; Filipa Mendes; António Paulo
Journal:  J Biol Inorg Chem       Date:  2018-11-24       Impact factor: 3.358

3.  A novel zinc bis(thiosemicarbazone) complex for live cell imaging.

Authors:  Disha Dayal; Duraippandi Palanimuthu; Sridevi Vijay Shinde; Kumaravel Somasundaram; Ashoka G Samuelson
Journal:  J Biol Inorg Chem       Date:  2011-03-08       Impact factor: 3.358

4.  Thiosemicarbazone-based selective proliferation inactivators inhibit gastric cancer cell growth, invasion, and migration.

Authors:  Biao Hu; Bo Wang; Bing Zhao; Qian Guo; Zhong-Hua Li; Xin-Hui Zhang; Guang-Yao Liu; Ying Liu; Ying Tang; Fan Luo; Ya Du; Ya-Xin Chen; Li-Ying Ma; Hong-Min Liu
Journal:  Medchemcomm       Date:  2017-10-23       Impact factor: 3.597

5.  Functional, Aromatic, and Fluorinated Monothiosemicarbazones: Investigations into Their Structures and Activity toward the Gallium-68 Incorporation by Microwave Irradiation.

Authors:  Sophia Sarpaki; Fernando Cortezon-Tamarit; Rüdiger Maria Exner; Kexin Song; Sara Raquel Mota Merelo de Aguiar; Haobo Ge; Charareh Pourzand; Stephen James Paisey; Gabriele Kociok-Köhn; Jonathan Robin Dilworth; Laurence Carroll; Sofia Ioana Pascu
Journal:  ACS Omega       Date:  2022-04-11

6.  Microwave gallium-68 radiochemistry for kinetically stable bis(thiosemicarbazone) complexes: structural investigations and cellular uptake under hypoxia.

Authors:  Israt S Alam; Rory L Arrowsmith; Fernando Cortezon-Tamarit; Frazer Twyman; Gabriele Kociok-Köhn; Stanley W Botchway; Jonathan R Dilworth; Laurence Carroll; Eric O Aboagye; Sofia I Pascu
Journal:  Dalton Trans       Date:  2016-01-07       Impact factor: 4.390
  6 in total

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