Literature DB >> 18395847

Restoring the balance: harnessing regulatory T cells for therapy in rheumatoid arthritis.

Fabian Flores-Borja1, Claudia Mauri, Michael R Ehrenstein.   

Abstract

Treg play a vital role in the maintenance of tolerance to self antigens, thereby preventing disease through the active suppression of proliferation and pro-inflammatory cytokine production by autoreactive T cells. Here we discuss strategies aimed at enhancing Treg function in patients with rheumatoid arthritis with the ultimate aim of restoring lasting tolerance but without increasing the risk of infections or cancer.

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Year:  2008        PMID： 18395847     DOI： 10.1002/eji.200738107

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  12 in total

1.  Protein kinase C-theta mediates negative feedback on regulatory T cell function.

Authors:  Alexandra Zanin-Zhorov; Yi Ding; Sudha Kumari; Mukundan Attur; Keli L Hippen; Maryanne Brown; Bruce R Blazar; Steven B Abramson; Juan J Lafaille; Michael L Dustin
Journal:  Science       Date:  2010-03-25       Impact factor: 47.728

2.  A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity.

Authors:  Urmila D Bajpai; Louise A Swainson; Jeff E Mold; Jonathan D Graf; John B Imboden; Joseph M McCune
Journal:  Arthritis Rheum       Date:  2012-08

Review 3.  Tolerogenic dendritic cells and rheumatoid arthritis: current status and perspectives.

Authors:  Yunpeng Zhao; Aijun Zhang; Hongxia Du; Shuya Guo; Bin Ning; Shangyou Yang
Journal:  Rheumatol Int       Date:  2011-09-09       Impact factor: 2.631

Review 4.  Manipulating regulatory T cells: a promising strategy to treat autoimmunity.

Authors:  Dunfang Zhang; Eric Tu; Shimpei Kasagi; Peter Zanvit; Qianming Chen; WanJun Chen
Journal:  Immunotherapy       Date:  2015-11-16       Impact factor: 4.196

5.  Tumour immunogenicity, antigen presentation and immunological barriers in cancer immunotherapy.

Authors:  David Escors
Journal:  New J Sci       Date:  2014-01-05

6.  Selective ERK activation differentiates mouse and human tolerogenic dendritic cells, expands antigen-specific regulatory T cells, and suppresses experimental inflammatory arthritis.

Authors:  Frederick Arce; Karine Breckpot; Holly Stephenson; Katarzyna Karwacz; Michael R Ehrenstein; Mary Collins; David Escors
Journal:  Arthritis Rheum       Date:  2011-01

7.  Antigen-specific tolerogenic dendritic cells ameliorate the severity of murine collagen-induced arthritis.

Authors:  Bin Ning; Jianlu Wei; Aijun Zhang; Weiming Gong; Jinqiu Fu; Tanghong Jia; Shang-You Yang
Journal:  PLoS One       Date:  2015-06-24       Impact factor: 3.240

8.  Amelioration of collagen-induced arthritis using antigen-loaded dendritic cells modified with NF-κB decoy oligodeoxynucleotides.

Authors:  Hongmei Jiang; Henggui Hu; Yali Zhang; Ping Yue; Lichang Ning; Yan Zhou; Ping Shi; Rui Yuan
Journal:  Drug Des Devel Ther       Date:  2017-10-13       Impact factor: 4.162

9.  MiR-129-5p regulates cell proliferation and apoptosis via IGF-1R/Src/ERK/Egr-1 pathway in RA-fibroblast-like synoviocytes.

Authors:  Yan Zhang; Ni Yan; Xiaoqing Wang; Yanhai Chang; Yu Wang
Journal:  Biosci Rep       Date:  2019-12-20       Impact factor: 3.840

Review 10.  Quantitative Predictive Modelling Approaches to Understanding Rheumatoid Arthritis: A Brief Review.

Authors:  Fiona R Macfarlane; Mark A J Chaplain; Raluca Eftimie
Journal:  Cells       Date:  2019-12-27       Impact factor: 6.600
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