| Literature DB >> 1839511 |
M L Candenas1, E Naline, L Puybasset, P Devillier, C Advenier.
Abstract
ANF, ANF7-28 and atriopeptins (AP1, AP2 and AP3) (10(-11) to 3 x 10(-7) M) induce a relaxant response on the guinea-pig isolated trachea, which is partially potentiated by the enkephalinase inhibitor thiorphan 10(-5) M but is unmodified by epithelium removal. Conversely, these drugs were found to be without any significant relaxant effect on the isolated human bronchus. Several hypotheses, such as the activation of ANF receptors not located on airway smooth muscle or an indirect effect of ANF in vivo are suggested to explain the discrepancy between these in vitro results and those of clinical trials in asthmatic subjects.Entities:
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Year: 1991 PMID： 1839511 DOI： 10.1016/0952-0600(91)90062-8
Source DB: PubMed Journal: Pulm Pharmacol ISSN： 0952-0600