Literature DB >> 18394985

A tRNA with oncogenic capacity.

Anton Berns1.   

Abstract

Overexpression of Brf1, a transcription factor of the RNA polymerase III apparatus, can transform cells in vitro and cause tumor formation in vivo. Marshall et al. (2008) now show that one of the transcriptional products of RNA polymerase III, the initiator tRNA(Met), mediates this effect, revealing an unexpected role for this tRNA in tumorigenesis.

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Year:  2008        PMID： 18394985     DOI： 10.1016/j.cell.2008.03.017

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  7 in total

1.  In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents.

Authors:  Séverine Denoyelle; Ting Chen; Limo Chen; Yibo Wang; Edvin Klosi; José A Halperin; Bertal H Aktas; Michael Chorev
Journal:  Bioorg Med Chem Lett       Date:  2011-11-16       Impact factor: 2.823

2.  Genomic analysis of circulating cell-free DNA infers breast cancer dormancy.

Authors:  Jacqueline A Shaw; Karen Page; Kevin Blighe; Natasha Hava; David Guttery; Becky Ward; James Brown; Chetana Ruangpratheep; Justin Stebbing; Rachel Payne; Carlo Palmieri; Suzy Cleator; Rosemary A Walker; R Charles Coombes
Journal:  Genome Res       Date:  2011-10-11       Impact factor: 9.043

3.  Structure of human cytomegalovirus virion reveals host tRNA binding to capsid-associated tegument protein pp150.

Authors:  Yun-Tao Liu; David Strugatsky; Wei Liu; Z Hong Zhou
Journal:  Nat Commun       Date:  2021-09-17       Impact factor: 17.694

4.  Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase.

Authors:  Ting Chen; Khuloud Takrouri; Sung Hee-Hwang; Sandeep Rana; Revital Yefidoff-Freedman; Jose Halperin; Amarnath Natarajan; Christophe Morisseau; Bruce Hammock; Michael Chorev; Bertal H Aktas
Journal:  J Med Chem       Date:  2013-11-27       Impact factor: 7.446

5.  Profiling of REST-Dependent microRNAs Reveals Dynamic Modes of Expression.

Authors:  Zhengliang Gao; Peiguo Ding; Jenny Hsieh
Journal:  Front Neurosci       Date:  2012-05-10       Impact factor: 4.677

6.  miR-34a directly targets tRNAiMet precursors and affects cellular proliferation, cell cycle, and apoptosis.

Authors:  Bo Wang; Dongping Li; Igor Kovalchuk; Ingrid J Apel; Arul M Chinnaiyan; Rafał K Wóycicki; Charles R Cantor; Olga Kovalchuk
Journal:  Proc Natl Acad Sci U S A       Date:  2018-06-25       Impact factor: 11.205

7.  The Effect of Dysregulation of tRNA Genes and Translation Efficiency Mutations in Cancer and Neurodegeneration.

Authors:  Tamir Tuller
Journal:  Front Genet       Date:  2012-10-12       Impact factor: 4.599
  7 in total

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