Literature DB >> 18393464

Aplysamine 6, an alkaloidal inhibitor of Isoprenylcysteine carboxyl methyltransferase from the sponge Pseudoceratina sp.

Malcolm S Buchanan1, Anthony R Carroll, Gregory A Fechner, Anthony Boyle, Moana Simpson, Rama Addepalli, Vicky M Avery, John N A Hooper, Tony Cheung, Huwei Chen, Ronald J Quinn.   

Abstract

The anticancer target isoprenylcysteine carboxyl methyltransferase (Icmt) was the focus of a natural product high-throughput screening campaign. The Australian marine sponge Pseudoceratina sp. yielded aplysamine 6, a new bromotyrosine derivative with an alpha,beta-unsaturated amide linkage, as the bioactive constituent. Its structure was determined by 1D and 2D NMR spectroscopy.

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Year:  2008        PMID： 18393464     DOI： 10.1021/np0706623

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  10 in total

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Journal:  Future Med Chem       Date:  2011-10       Impact factor: 3.808

Review 2.  Small change, big effect: Taking RAS by the tail through suppression of post-prenylation carboxylmethylation.

Authors:  Hiu Yeung Lau; Mei Wang
Journal:  Small GTPases       Date:  2018-01-25

3.  The development of a general strategy for the synthesis of tyramine-based natural products by using continuous flow techniques.

Authors:  Srinivas Achanta; Virginie Liautard; Robert Paugh; Michael G Organ
Journal:  Chemistry       Date:  2010-11-15       Impact factor: 5.236

4.  The Antileukemic and Anti-Prostatic Effect of Aeroplysinin-1 Is Mediated through ROS-Induced Apoptosis via NOX Activation and Inhibition of HIF-1a Activity.

Authors:  Shou-Ping Shih; Mei-Chin Lu; Mohamed El-Shazly; Yu-Hsuan Lin; Chun-Lin Chen; Steve Sheng-Fa Yu; Yi-Chang Liu
Journal:  Life (Basel)       Date:  2022-05-05

5.  Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase.

Authors:  Kyle V Butler; Kelsey Bohn; Christine A Hrycyna; Jian Jin
Journal:  Medchemcomm       Date:  2016-04-14       Impact factor: 3.597

6.  A Model Study toward the Concise Synthesis of Bromotyrosine Derived Spiroisoxazoline Natural Products and Analogous Core Structures.

Authors:  Prasanta Das; Edward J Valente; Ashton T Hamme
Journal:  European J Org Chem       Date:  2014-05-01

Review 7.  Isoprenyl carboxyl methyltransferase inhibitors: a brief review including recent patents.

Authors:  Woo Seok Yang; Seung-Gu Yeo; Sungjae Yang; Kyung-Hee Kim; Byong Chul Yoo; Jae Youl Cho
Journal:  Amino Acids       Date:  2017-06-19       Impact factor: 3.520

8.  Sponge chemical defenses are a possible mechanism for increasing sponge abundance on reefs in Zanzibar.

Authors:  Stephanie B Helber; Dieuwke J J Hoeijmakers; Christopher A Muhando; Sven Rohde; Peter J Schupp
Journal:  PLoS One       Date:  2018-06-20       Impact factor: 3.240

9.  Antiplasmodial activities of homogentisic acid derivative protein kinase inhibitors isolated from a Vanuatu marine sponge Pseudoceratina sp.

Authors:  Nicolas Lebouvier; Valérie Jullian; Isabelle Desvignes; Séverine Maurel; Arnaud Parenty; Dominique Dorin-Semblat; Christian Doerig; Michel Sauvain; Dominique Laurent
Journal:  Mar Drugs       Date:  2009-11-23       Impact factor: 5.118

10.  Towards the small and the beautiful: a small dibromotyrosine derivative from Pseudoceratina sp. sponge exhibits potent apoptotic effect through targeting IKK/NFκB signaling pathway.

Authors:  Jui-Hsin Su; Yu-Cheng Chen; Mohamed El-Shazly; Ying-Chi Du; Chiang-Wen Su; Chia-Wei Tsao; Li-Lian Liu; Yalan Chou; Wen-Been Chang; Yin-Di Su; Michael Y Chiang; Yao-Tsung Yeh; Mei-Chin Lu
Journal:  Mar Drugs       Date:  2013-08-26       Impact factor: 5.118
  10 in total

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