Yuan Yang1, He Tian, Zhi-jun Zhang. 1. Department of Laboratory Medicine, Huaihua Medical College, Huaihua, Hunan, 418000 P. R. China. yang1977yuan@yahoo.com.cn
Abstract
OBJECTIVE: To evaluate the association between the polymorphisms of X-ray repair cross complementing group 1 (XRCC1) and human 8-oxoguanine glycosylase I (hOGG1) gene and the risk for laryngeal carcinoma. METHODS: This is a case-control study comprised of two groups: 72 patients with laryngeal squamous carcinoma, and 72 controls without laryngeal carcinoma. The PCR-restriction fragment length polymorphism method was used to analyze the XRCC1-Arg399Gln, hOGG1-Ser326Cys polymorphisms. RESULTS: The frequencies of XRCC1-399Arg/Gln+ Gln/Gln and hOGG1-326Ser/Cys+ Cys/Cys genotypes in the case group were higher than that of the control group(P< 0.05). There was a 3.37-fold or 2.54-fold increased risk of laryngeal carcinoma for individuals carrying XRCC1-399Arg/Gln+ Gln/Gln or hOGG1-326Ser/Cys+ Cys/Cys genotypes, compared with subjects carrying XRCC1-Arg/Arg or hOGG1-Ser/Ser genotype, respectively. No statistically significant differences were found between the smoking group and non-smoking group for risk of laryngeal carcinoma. CONCLUSION: The amino acid replacement of XRCC1-399Arg to Gln and hOGG1-326Ser to Cys might lead to an increased risk of laryngeal carcinoma. The study demonstrated the positive association between the polymorphisms of XRCC1 and hOGG1 genes and laryngeal carcinoma.
OBJECTIVE: To evaluate the association between the polymorphisms of X-ray repair cross complementing group 1 (XRCC1) and human 8-oxoguanine glycosylase I (hOGG1) gene and the risk for laryngeal carcinoma. METHODS: This is a case-control study comprised of two groups: 72 patients with laryngeal squamous carcinoma, and 72 controls without laryngeal carcinoma. The PCR-restriction fragment length polymorphism method was used to analyze the XRCC1-Arg399Gln, hOGG1-Ser326Cys polymorphisms. RESULTS: The frequencies of XRCC1-399Arg/Gln+ Gln/Gln and hOGG1-326Ser/Cys+ Cys/Cys genotypes in the case group were higher than that of the control group(P< 0.05). There was a 3.37-fold or 2.54-fold increased risk of laryngeal carcinoma for individuals carrying XRCC1-399Arg/Gln+ Gln/Gln or hOGG1-326Ser/Cys+ Cys/Cys genotypes, compared with subjects carrying XRCC1-Arg/Arg or hOGG1-Ser/Ser genotype, respectively. No statistically significant differences were found between the smoking group and non-smoking group for risk of laryngeal carcinoma. CONCLUSION: The amino acid replacement of XRCC1-399Arg to Gln and hOGG1-326Ser to Cys might lead to an increased risk of laryngeal carcinoma. The study demonstrated the positive association between the polymorphisms of XRCC1 and hOGG1 genes and laryngeal carcinoma.
Authors: Camille Ragin; Monisola Obikoya-Malomo; Sungjin Kim; Zhengjia Chen; Rafael Flores-Obando; Denise Gibbs; Chihaya Koriyama; Francisco Aguayo; Jill Koshiol; Neil E Caporaso; Giovanna E Carpagnano; Marco Ciotti; Hirotoshi Dosaka-Akita; Masashi Fukayama; Akiteru Goto; Demetrios A Spandidos; Vassilis Gorgoulis; Daniëlle A M Heideman; Robert A A van Boerdonk; Kenzo Hiroshima; Reika Iwakawa; Nikolaos G Kastrinakis; Ichiro Kinoshita; Suminori Akiba; Maria T Landi; H Eugene Liu; Jinn-Li Wang; Ranee Mehra; Fadlo R Khuri; Wan-Teck Lim; Taofeek K Owonikoko; Suresh Ramalingam; Emmanuela Sarchianaki; Kari Syrjanen; Ming-Sound Tsao; Jenna Sykes; Siew Wan Hee; Jun Yokota; Apostolos Zaravinos; Emanuela Taioli Journal: Carcinogenesis Date: 2014-02-12 Impact factor: 4.944