Cost-effectiveness analysis of the analgesic therapy of postoperative pain.

The study aimed to compare cost-effectiveness of analgesic schemes administered to 89 patients submitted to hemorrhoidectomy, on the 1st postoperative day. The descriptive and retrospective study was carried out in a General Hospital, Sao Paulo, Brazil. In order to carry out the cost-effectiveness analysis, the five most frequently used analgesic schemes were identified in practice. The main outcome was the absence of breakthrough pain episodes. While calculating the costs, analgesics and all devices related to the schemes were taken into consideration. Codeine 120 mg+acetaminophen 2000 mg was the most effective therapy with the lowest cost per patient with no breakthrough pain episodes ($65.23). Incremental analysis indicated that codeine 120 mg+acetaminophen 2000 mg+ketoprofen 200 mg involved the additional cost of $238.31 in case an extra effectiveness benefit was needed. The analysis showed that the most suitable choice of analgesic therapy should consider the resources available at the institution along with economic and clinical aspects.