Literature DB >> 18392169

Challenges associated with controlled psychopharmacological research trials in adolescents with eating disorders.

Mark L Norris1, Wendy Spettigue, Annick Buchholz, Katherine A Henderson.   

Abstract

INTRODUCTION: Eating disordered populations present many unique challenges both to clinicians and researchers. Adolescents with eating disorders can be difficult to treat, and the challenges associated with research in this area can be significant.
OBJECTIVES: This paper was written with three main objectives in mind: to comment on some of the barriers impeding mental health research in general, to highlight challenges faced in the design and implementation of ED-specific studies, and to integrate personal insight into some of the many challenges that we have encountered during our experience with a randomized clinical trial examining the efficacy of olanzapine for the adjunctive treatment of youth with Anorexia Nervosa. DISCUSSION: It is hoped that providing information in this context will allow researchers greater insight into some of the many challenges that accompany study of this cohort.

Entities:  

Keywords:  adolescents; challenges; eating disorders; obstacles; research

Year:  2007        PMID: 18392169      PMCID: PMC2247458     

Source DB:  PubMed          Journal:  J Can Acad Child Adolesc Psychiatry        ISSN: 1719-8429


  13 in total

1.  Olanzapine use as an adjunctive treatment for hospitalized children with anorexia nervosa: case reports.

Authors:  Ahmed Boachie; Gary S Goldfield; Wendy Spettigue
Journal:  Int J Eat Disord       Date:  2003-01       Impact factor: 4.861

Review 2.  Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review.

Authors:  John W Newcomer
Journal:  CNS Drugs       Date:  2005       Impact factor: 5.749

Review 3.  Medication development and testing in children and adolescents. Current problems, future directions.

Authors:  B Vitiello; P S Jensen
Journal:  Arch Gen Psychiatry       Date:  1997-09

Review 4.  Outcomes of eating disorders: a systematic review of the literature.

Authors:  Nancy D Berkman; Kathleen N Lohr; Cynthia M Bulik
Journal:  Int J Eat Disord       Date:  2007-05       Impact factor: 4.861

5.  Olanzapine in children and adolescents with chronic anorexia nervosa. A study of five cases.

Authors:  C Mehler; C Wewetzer; U Schulze; A Warnke; F Theisen; R W Dittmann
Journal:  Eur Child Adolesc Psychiatry       Date:  2001-06       Impact factor: 4.785

6.  Olanzapine treatment of anorexia nervosa: a retrospective study.

Authors:  Amanda Malina; Jill Gaskill; Claire McConaha; Guido K Frank; Maria LaVia; Lisa Scholar; Walter H Kaye
Journal:  Int J Eat Disord       Date:  2003-03       Impact factor: 4.861

7.  Ethics and mental illness research.

Authors:  Laura Weiss Roberts
Journal:  Psychiatr Clin North Am       Date:  2002-09

8.  Report of the National Institutes of Health workshop on overcoming barriers to treatment research in anorexia nervosa.

Authors:  W Stewart Agras; Harry A Brandt; Cynthia M Bulik; Regina Dolan-Sewell; Christopher G Fairburn; Katherine A Halmi; David B Herzog; David C Jimerson; Allan S Kaplan; Walter H Kaye; Daniel le Grange; James Lock; James E Mitchell; Matthew V Rudorfer; Linda L Street; Ruth Striegel-Moore; Kelly M Vitousek; B Timothy Walsh; Denise E Wilfley
Journal:  Int J Eat Disord       Date:  2004-05       Impact factor: 4.861

9.  AACAP 2001 research forum: challenges and recommendations regarding recruitment and retention of participants in research investigations.

Authors:  Stephen P Hinshaw; Kimberly Hoagwood; Peter S Jensen; Christopher Kratochvil; Leonard Bickman; Greg Clarke; Howard B Abikoff; Marc Atkins; Benedetto Vitiello
Journal:  J Am Acad Child Adolesc Psychiatry       Date:  2004-08       Impact factor: 8.829

Review 10.  Challenges in medication clinical trials.

Authors:  M V Rudorfer
Journal:  Psychopharmacol Bull       Date:  1993
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  2 in total

1.  The household economic burden of eating disorders and adherence to treatment in Australia.

Authors:  Lauren Gatt; Stephen Jan; Naresh Mondraty; Sarah Horsfield; Susan Hart; Janice Russell; Tracey Lea Laba; Beverley Essue
Journal:  BMC Psychiatry       Date:  2014-11-29       Impact factor: 3.630

2.  "Include me if you can"-reasons for low enrollment of pediatric patients in a psychopharmacological trial.

Authors:  Larissa Niemeyer; Konstantin Mechler; Jan Buitelaar; Sarah Durston; Bram Gooskens; Bob Oranje; Tobias Banaschewski; Ralf W Dittmann; Alexander Häge
Journal:  Trials       Date:  2021-03-01       Impact factor: 2.279

  2 in total

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