Literature DB >> 18391961

Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years.

Ivar Mendez1, Angel Viñuela, Arnar Astradsson, Karim Mukhida, Penelope Hallett, Harold Robertson, Travis Tierney, Renn Holness, Alain Dagher, John Q Trojanowski, Ole Isacson.   

Abstract

Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.

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Year:  2008        PMID： 18391961      PMCID： PMC2656682          DOI： 10.1038/nm1752

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  14 in total

1.  Differential expression and distribution of alpha-, beta-, and gamma-synuclein in the developing human substantia nigra.

Authors:  J E Galvin; T M Schuck; V M Lee; J Q Trojanowski
Journal:  Exp Neurol       Date:  2001-04       Impact factor: 5.330

2.  Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes.

Authors:  Neeta S Roy; Carine Cleren; Shashi K Singh; Lichuan Yang; M Flint Beal; Steven A Goldman
Journal:  Nat Med       Date:  2006-10-22       Impact factor: 53.440

Review 3.  Molecular pathogenesis of Parkinson disease.

Authors:  Jason L Eriksen; Zbigniew Wszolek; Leonard Petrucelli
Journal:  Arch Neurol       Date:  2005-03

4.  Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

Authors:  M Baba; S Nakajo; P H Tu; T Tomita; K Nakaya; V M Lee; J Q Trojanowski; T Iwatsubo
Journal:  Am J Pathol       Date:  1998-04       Impact factor: 4.307

Review 5.  Toward full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease by stem cells.

Authors:  Ole Isacson; Lars M Bjorklund; James M Schumacher
Journal:  Ann Neurol       Date:  2003       Impact factor: 10.422

6.  Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease.

Authors:  Ivar Mendez; Rosario Sanchez-Pernaute; Oliver Cooper; Angel Viñuela; Daniela Ferrari; Lars Björklund; Alain Dagher; Ole Isacson
Journal:  Brain       Date:  2005-05-04       Impact factor: 13.501

Review 7.  The cellular pathology of Parkinson's disease.

Authors:  H Takahashi; K Wakabayashi
Journal:  Neuropathology       Date:  2001-12       Impact factor: 1.906

8.  Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats.

Authors:  Manolo Carta; Thomas Carlsson; Deniz Kirik; Anders Björklund
Journal:  Brain       Date:  2007-04-23       Impact factor: 13.501

9.  Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease.

Authors:  Thomas Carlsson; Manolo Carta; Christian Winkler; Anders Björklund; Deniz Kirik
Journal:  J Neurosci       Date:  2007-07-25       Impact factor: 6.167

10.  Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations.

Authors:  Jan Pruszak; Kai-Christian Sonntag; Moe Hein Aung; Rosario Sanchez-Pernaute; Ole Isacson
Journal:  Stem Cells       Date:  2007-06-21       Impact factor: 6.277
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  157 in total

Review 1.  Using stem cells and iPS cells to discover new treatments for Parkinson's disease.

Authors:  Oliver Cooper; Penny Hallett; Ole Isacson
Journal:  Parkinsonism Relat Disord       Date:  2012-01       Impact factor: 4.891

Review 2.  Intercellular (mis)communication in neurodegenerative disease.

Authors:  Gwenn A Garden; Albert R La Spada
Journal:  Neuron       Date:  2012-03-08       Impact factor: 17.173

Review 3.  Multiple system atrophy: a clinical and neuropathological perspective.

Authors:  Kiren Ubhi; Phillip Low; Eliezer Masliah
Journal:  Trends Neurosci       Date:  2011-09-29       Impact factor: 13.837

4.  Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains.

Authors:  Shanshan Wang; Michael S Okun; Oleg Suslov; Tong Zheng; Nikolaus R McFarland; Vinata Vedam-Mai; Kelly D Foote; Steven N Roper; Anthony T Yachnis; Florian A Siebzehnrubl; Dennis A Steindler
Journal:  Brain Res       Date:  2012-04-27       Impact factor: 3.252

Review 5.  Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.

Authors:  Nicole Exner; Anne Kathrin Lutz; Christian Haass; Konstanze F Winklhofer
Journal:  EMBO J       Date:  2012-06-26       Impact factor: 11.598

6.  Being too inclusive about synuclein inclusions.

Authors:  Ole Isacson; Ivar Mendez
Journal:  Nat Med       Date:  2010-09       Impact factor: 53.440

Review 7.  Missing pieces in the Parkinson's disease puzzle.

Authors:  Jose A Obeso; Maria C Rodriguez-Oroz; Christopher G Goetz; Concepcion Marin; Jeffrey H Kordower; Manuel Rodriguez; Etienne C Hirsch; Matthew Farrer; Anthony H V Schapira; Glenda Halliday
Journal:  Nat Med       Date:  2010-05-23       Impact factor: 53.440

Review 8.  Parkinson's disease therapeutics: new developments and challenges since the introduction of levodopa.

Authors:  Yoland Smith; Thomas Wichmann; Stewart A Factor; Mahlon R DeLong
Journal:  Neuropsychopharmacology       Date:  2011-09-28       Impact factor: 7.853

9.  Proceedings: cell therapies for Parkinson's disease from discovery to clinic.

Authors:  Rosa Canet-Aviles; Geoffrey P Lomax; Ellen G Feigal; Catherine Priest
Journal:  Stem Cells Transl Med       Date:  2014-08-22       Impact factor: 6.940

10.  Relationship of neighboring tissue and gliosis to α-synuclein pathology in a fetal transplant for Parkinson's disease.

Authors:  Tae-Beom Ahn; J William Langston; Venkat Raghav Aachi; Dennis W Dickson
Journal:  Am J Neurodegener Dis       Date:  2012-04-18
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