BACKGROUND/AIMS: Abnormal processing of hyperphosphorylated tau (HPtau), amyloid-beta (Abeta) and alpha-synuclein (alphaS) proteins is considered as causative with regard to the clinical symptoms in age-related neurodegenerative diseases. METHODS: In this retrospective, postmortem study applying immunohistochemical methodology, we assessed Alzheimer's-disease (AD)-related HPtau and Abeta pathology in 178 subjects with alphaS pathology. RESULTS: These pathologies were frequently seen concomitantly, i.e. HPtau in 83% and Abeta in 62% of the alphaS-positive cases. Furthermore, the striatum was frequently involved, particularly in subjects with cognitive impairment (65%). The predictive value of widespread HPtau pathology, i.e. stages V-VI, with respect to cognitive impairment was high, since all 18 subjects presenting with this stage were demented. In contrast, the predictive value of widespread alphaS pathology, i.e. stages 5-6 according to Braak's Parkinson disease staging, was debatable. Fifty-three percent of the subjects with widespread alphaS pathology and no or mild AD-related HPtau pathology were cognitively unimpaired. It is noteworthy that striatal Abeta pathology was more often seen in demented subjects independently of HPtau and/or alphaS status. CONCLUSION: The causative pathology in subjects with clinically diagnosed dementia with Lewy bodies needs to be clarified in future studies. (c) 2008 S. Karger AG, Basel
BACKGROUND/AIMS: Abnormal processing of hyperphosphorylated tau (HPtau), amyloid-beta (Abeta) and alpha-synuclein (alphaS) proteins is considered as causative with regard to the clinical symptoms in age-related neurodegenerative diseases. METHODS: In this retrospective, postmortem study applying immunohistochemical methodology, we assessed Alzheimer's-disease (AD)-related HPtau and Abeta pathology in 178 subjects with alphaS pathology. RESULTS: These pathologies were frequently seen concomitantly, i.e. HPtau in 83% and Abeta in 62% of the alphaS-positive cases. Furthermore, the striatum was frequently involved, particularly in subjects with cognitive impairment (65%). The predictive value of widespread HPtau pathology, i.e. stages V-VI, with respect to cognitive impairment was high, since all 18 subjects presenting with this stage were demented. In contrast, the predictive value of widespread alphaS pathology, i.e. stages 5-6 according to Braak's Parkinson disease staging, was debatable. Fifty-three percent of the subjects with widespread alphaS pathology and no or mild AD-related HPtau pathology were cognitively unimpaired. It is noteworthy that striatal Abeta pathology was more often seen in demented subjects independently of HPtau and/or alphaS status. CONCLUSION: The causative pathology in subjects with clinically diagnosed dementia with Lewy bodies needs to be clarified in future studies. (c) 2008 S. Karger AG, Basel
Authors: Kiren Ubhi; Kevin Peng; Stephanie Lessig; Jennilyn Estrella; Anthony Adame; Douglas Galasko; David P Salmon; Lawrence A Hansen; Claudia H Kawas; Eliezer Masliah Journal: Neurosci Lett Date: 2010-09-21 Impact factor: 3.046
Authors: Irina Alafuzoff; Dietmar R Thal; Thomas Arzberger; Nenad Bogdanovic; Safa Al-Sarraj; Istvan Bodi; Susan Boluda; Orso Bugiani; Charles Duyckaerts; Ellen Gelpi; Stephen Gentleman; Giorgio Giaccone; Manuel Graeber; Tibor Hortobagyi; Romana Höftberger; Paul Ince; James W Ironside; Nikolaos Kavantzas; Andrew King; Penelope Korkolopoulou; Gábor G Kovács; David Meyronet; Camelia Monoranu; Tatjana Nilsson; Piero Parchi; Efstratios Patsouris; Maria Pikkarainen; Tamas Revesz; Annemieke Rozemuller; Danielle Seilhean; Walter Schulz-Schaeffer; Nathalie Streichenberger; Stephen B Wharton; Hans Kretzschmar Journal: Acta Neuropathol Date: 2009-02-01 Impact factor: 17.088
Authors: Lilia Zurkovsky; Evgeny Bychkov; Elviche L Tsakem; Carley Siedlecki; Randy D Blakely; Eugenia V Gurevich Journal: Dis Model Mech Date: 2012-08-03 Impact factor: 5.758