Literature DB >> 18391466

Low-molecular-weight hyaluronan permeates through human intestinal Caco-2 cell monolayers via the paracellular pathway.

Nozomi Hisada1, Hideo Satsu, Akira Mori, Mamoru Totsuka, Jun-ichi Kamei, Takashi Nozawa, Makoto Shimizu.   

Abstract

The intestinal permeability of low-molecular-weight hyaluronan (LMW-HA) was investigated by using cultured monolayers of Caco-2 cells. The amount of LMW-HA that permeated the Caco-2 monolayers was measured by a carbazole assay. The permeability of LMW-HA increased inversely with the molecular size and was dose-dependent. The transport was observed to be energy-independent, and was correlated with the tight junction (TJ) permeability. These results suggest that LMW-HA permeated the Caco-2 cell monolayers via the paracellular pathway.

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Year:  2008        PMID： 18391466     DOI： 10.1271/bbb.70748

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  15 in total

1.  Short-term effect of the combination of hyaluronic acid, chondroitin sulfate, and keratin matrix on early symptomatic knee osteoarthritis.

Authors:  Felice Galluccio; Tatiana Barskova; Marco Matucci Cerinic
Journal:  Eur J Rheumatol       Date:  2015-09-01

2.  Human milk hyaluronan enhances innate defense of the intestinal epithelium.

Authors:  David R Hill; Hyunjin K Rho; Sean P Kessler; Ripal Amin; Craig R Homer; Christine McDonald; Mary K Cowman; Carol A de la Motte
Journal:  J Biol Chem       Date:  2013-08-15       Impact factor: 5.157

3.  Characterization of CD44-mediated cancer cell uptake and intracellular distribution of hyaluronan-grafted liposomes.

Authors:  Hussaini Syed Sha Qhattal; Xinli Liu
Journal:  Mol Pharm       Date:  2011-07-05       Impact factor: 4.939

4.  MicroRNA 181b-3p and its target importin α5 regulate toll-like receptor 4 signaling in Kupffer cells and liver injury in mice in response to ethanol.

Authors:  Paramananda Saikia; Damien Bellos; Megan R McMullen; Katherine A Pollard; Carol de la Motte; Laura E Nagy
Journal:  Hepatology       Date:  2017-07-04       Impact factor: 17.425

Review 5.  Role and Effectiveness of Intra-articular Injection of Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Systematic Review.

Authors:  Sumant Chavda; Syed Arman Rabbani; Tarun Wadhwa
Journal:  Cureus       Date:  2022-04-26

6.  Intestinal absorption of fucoidan extracted from the brown seaweed, Cladosiphon okamuranus.

Authors:  Takeaki Nagamine; Kyoumi Nakazato; Satoru Tomioka; Masahiko Iha; Katsuyuki Nakajima
Journal:  Mar Drugs       Date:  2014-12-25       Impact factor: 5.118

7.  Ingestion of hyaluronans (molecular weights 800 k and 300 k) improves dry skin conditions: a randomized, double blind, controlled study.

Authors:  Chinatsu Kawada; Takushi Yoshida; Hideto Yoshida; Wakako Sakamoto; Wataru Odanaka; Toshihide Sato; Takeshi Yamasaki; Tomoyuki Kanemitsu; Yasunobu Masuda; Osamu Urushibata
Journal:  J Clin Biochem Nutr       Date:  2014-11-01       Impact factor: 3.114

8.  Dietary hyaluronic acid migrates into the skin of rats.

Authors:  Mariko Oe; Koichi Mitsugi; Wataru Odanaka; Hideto Yoshida; Ryosuke Matsuoka; Satoshi Seino; Tomoyuki Kanemitsu; Yasunobu Masuda
Journal:  ScientificWorldJournal       Date:  2014-10-14

Review 9.  Ingested hyaluronan moisturizes dry skin.

Authors:  Chinatsu Kawada; Takushi Yoshida; Hideto Yoshida; Ryosuke Matsuoka; Wakako Sakamoto; Wataru Odanaka; Toshihide Sato; Takeshi Yamasaki; Tomoyuki Kanemitsu; Yasunobu Masuda; Osamu Urushibata
Journal:  Nutr J       Date:  2014-07-11       Impact factor: 3.271

10.  A high molecular weight hyaluronic acid biphasic dispersion as potential therapeutics for interstitial cystitis.

Authors:  Peadar R Rooney; Vijaya Krishna Kannala; Niranjan G Kotla; Ana Benito; Damien Dupin; Iraida Loinaz; Leo R Quinlan; Yury Rochev; Abhay Pandit
Journal:  J Biomed Mater Res B Appl Biomater       Date:  2020-10-26       Impact factor: 3.368
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