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Literature DB >> 18390662

The Methanothermobacter thermautotrophicus Cdc6-2 protein, the putative helicase loader, dissociates the minichromosome maintenance helicase.

Jae-Ho Shin¹, Gun Young Heo, Zvi Kelman.

Abstract

The Cdc6-1 and -2 proteins from the archaeon Methanothermobacter thermautotrophicus were previously shown to bind the minichromosome maintenance (MCM) helicase. It is shown here that Cdc6-2 protein dissociates the MCM complex. This observation supports the hypothesis that the Cdc6-2 protein functions as a helicase loader.

Entities: Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18390662 PMCID： PMC2395041 DOI： 10.1128/JB.00233-08

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

25 in total

1. Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control.

Authors: J Liu; C L Smith; D DeRyckere; K DeAngelis; G S Martin; J M Berger
Journal: Mol Cell Date: 2000-09 Impact factor: 17.970

Review 2. Common domains in the initiators of DNA replication in Bacteria, Archaea and Eukarya: combined structural, functional and phylogenetic perspectives.

Authors: Rafael Giraldo
Journal: FEMS Microbiol Rev Date: 2003-01 Impact factor: 16.408

3. A rotary pumping model for helicase function of MCM proteins at a distance from replication forks.

Authors: Ronald A Laskey; Mark A Madine
Journal: EMBO Rep Date: 2003-01 Impact factor: 8.807

4. Regulation of minichromosome maintenance helicase activity by Cdc6.

Authors: Jae-Ho Shin; Beatrice Grabowski; Rajesh Kasiviswanathan; Stephen D Bell; Zvi Kelman
Journal: J Biol Chem Date: 2003-07-01 Impact factor: 5.157

Review 5. Archaea: an archetype for replication initiation studies?

Authors: Lori M Kelman; Zvi Kelman
Journal: Mol Microbiol Date: 2003-05 Impact factor: 3.501

6. The intrinsic DNA helicase activity of Methanobacterium thermoautotrophicum delta H minichromosome maintenance protein.

Authors: D F Shechter; C Y Ying; J Gautier
Journal: J Biol Chem Date: 2000-05-19 Impact factor: 5.157

7. The single minichromosome maintenance protein of Methanobacterium thermoautotrophicum DeltaH contains DNA helicase activity.

Authors: Z Kelman; J K Lee; J Hurwitz
Journal: Proc Natl Acad Sci U S A Date: 1999-12-21 Impact factor: 11.205

8. Autophosphorylation of archaeal Cdc6 homologues is regulated by DNA.

Authors: B Grabowski; Z Kelman
Journal: J Bacteriol Date: 2001-09 Impact factor: 3.490

9. A conserved mechanism for replication origin recognition and binding in archaea.

Authors: Alan I Majerník; James P J Chong
Journal: Biochem J Date: 2008-01-15 Impact factor: 3.857

Review 10. Replicative helicase loaders: ring breakers and ring makers.

Authors: Megan J Davey; Mike O'Donnell
Journal: Curr Biol Date: 2003-08-05 Impact factor: 10.834

6 in total

1. Localized melting of duplex DNA by Cdc6/Orc1 at the DNA replication origin in the hyperthermophilic archaeon Pyrococcus furiosus.

Authors: Fujihiko Matsunaga; Kie Takemura; Masaki Akita; Akinori Adachi; Takeshi Yamagami; Yoshizumi Ishino
Journal: Extremophiles Date: 2009-09-30 Impact factor: 2.395