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Literature DB >> 18388896

Elevated soluble lectin-like oxidized LDL receptor-1 (sLOX-1) levels in obese postmenopausal women.

Tina E Brinkley¹, Noriaki Kume, Hirokazu Mitsuoka, Dana A Phares, James M Hagberg.

Abstract

We investigated the association between soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels and obesity in older women. Fifty-one postmenopausal women (10 lean, 22 overweight, and 19 obese) were included in this small retrospective analysis. Plasma sLOX-1 levels were measured using a chemiluminescent enzyme-linked immunoassay. Plasma levels of sLOX-1 were significantly higher in obese women (55.33 +/- 4.49 pg/ml) compared to lean (30.91 +/- 6.19 pg/ml, P = 0.002) and overweight women (38.31 +/- 4.18 pg/ml, P = 0.017). Plasma sLOX-1 levels were positively associated with body weight, BMI, total body fat, and trunk fat. The relationship between sLOX-1 and BMI was attenuated after adjustment for age, hormone replacement therapy, and body fat. In conclusion, obese women have higher sLOX-1 levels, which may reflect increased LOX-1 expression in adipose tissue.

Entities: Disease Gene Species

Mesh：

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Year: 2008 PMID： 18388896 PMCID： PMC2677801 DOI： 10.1038/oby.2008.213

Source DB: PubMed Journal: Obesity (Silver Spring) ISSN： 1930-7381 Impact factor: 5.002

11 in total

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Authors: Jawahar L Mehta; Jiawei Chen; Paul L Hermonat; Francesco Romeo; Giuseppe Novelli
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7. Endurance exercise training raises high-density lipoprotein cholesterol and lowers small low-density lipoprotein and very low-density lipoprotein independent of body fat phenotypes in older men and women.

Authors: Amy Halverstadt; Dana A Phares; Kenneth R Wilund; Andrew P Goldberg; James M Hagberg
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Review 8. Roles of lectin-like oxidized LDL receptor-1 and its soluble forms in atherogenesis.

Authors: N Kume; T Kita
Journal: Curr Opin Lipidol Date: 2001-08 Impact factor: 4.776

Review 9. LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis.

Authors: Mingyi Chen; Tomoh Masaki; Tatsuya Sawamura
Journal: Pharmacol Ther Date: 2002-07 Impact factor: 12.310

10. Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels are elevated in acute coronary syndrome: a novel marker for early diagnosis.

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3. Soluble Lectin-Like Oxidized LDL Receptor 1 as a Possible Mediator of Endothelial Dysfunction in Patients With Metabolic Syndrome.

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Review 4. Innate immune activation in obesity.

Authors: Carey N Lumeng
Journal: Mol Aspects Med Date: 2012-10-13

5. Caloric restriction, aerobic exercise training and soluble lectin-like oxidized LDL receptor-1 levels in overweight and obese post-menopausal women.

Authors: T E Brinkley; X Wang; N Kume; H Mitsuoka; B J Nicklas
Journal: Int J Obes (Lond) Date: 2010-09-21 Impact factor: 5.095

10. Oxidized LDL triggers pro-oncogenic signaling in human breast mammary epithelial cells partly via stimulation of MiR-21.

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