Literature DB >> 18388135

Reduced vascular tetrahydrobiopterin (BH4) and endothelial function with ageing: is it time for a chronic BH4 supplementation trial in middle-aged and older adults?

Gary L Pierce1, Thomas J Larocca.   

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Year:  2008        PMID： 18388135      PMCID： PMC2536576          DOI： 10.1113/jphysiol.2008.154229

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


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  6 in total

1.  Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults.

Authors:  Iratxe Eskurza; Laura A Myerburgh; Zachary D Kahn; Douglas R Seals
Journal:  J Physiol       Date:  2005-09-01       Impact factor: 5.182

2.  Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers : evidence for a dysfunctional nitric oxide synthase.

Authors:  T Heitzer; C Brockhoff; B Mayer; A Warnholtz; H Mollnau; S Henne; T Meinertz; T Münzel
Journal:  Circ Res       Date:  2000-02-04       Impact factor: 17.367

3.  Mechanisms of aging-induced impairment of endothelium-dependent relaxation: role of tetrahydrobiopterin.

Authors:  Katherine A Blackwell; Joseph P Sorenson; Darcy M Richardson; Leslie A Smith; Osamu Suda; Karl Nath; Zvonimir S Katusic
Journal:  Am J Physiol Heart Circ Physiol       Date:  2004-08-19       Impact factor: 4.733

4.  Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles.

Authors:  Michael D Delp; Bradley J Behnke; Scott A Spier; Guoyao Wu; Judy M Muller-Delp
Journal:  J Physiol       Date:  2007-12-06       Impact factor: 5.182

5.  Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction.

Authors:  Lakshmi Santhanam; Hyun Kyo Lim; Hyun Kyoung Lim; Victor Miriel; Tashalee Brown; Meet Patel; Sarit Balanson; Sungwoo Ryoo; Mirinda Anderson; Kaikobad Irani; Firdous Khanday; Luigi Di Costanzo; Daniel Nyhan; Joshua M Hare; David W Christianson; Richard Rivers; Artin Shoukas; Dan E Berkowitz
Journal:  Circ Res       Date:  2007-08-17       Impact factor: 17.367

Review 6.  The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications.

Authors:  Jeannette Vásquez-Vivar; B Kalyanaraman; Pavel Martásek
Journal:  Free Radic Res       Date:  2003-02
  6 in total
  12 in total

1.  Exercising an option to prevent age related decline of vascular BH4 and uncoupling of eNOS.

Authors:  James W E Rush
Journal:  J Physiol       Date:  2009-08-01       Impact factor: 5.182

Review 2.  Estrogen signaling and cardiovascular disease.

Authors:  Elizabeth Murphy
Journal:  Circ Res       Date:  2011-09-02       Impact factor: 17.367

Review 3.  Arterial structure and function in vascular ageing: are you as old as your arteries?

Authors:  Dick H J Thijssen; Sophie E Carter; Daniel J Green
Journal:  J Physiol       Date:  2015-07-27       Impact factor: 5.182

4.  Age-related changes in an antioxidant defense system in elderly patients with essential hypertension compared with healthy controls.

Authors:  Joanna Rybka; Daria Kupczyk; Kornelia Kędziora-Kornatowska; Hanna Pawluk; Jolanta Czuczejko; Karolina Szewczyk-Golec; Mariusz Kozakiewicz; Marco Antonioli; Livia A Carvalho; Józef Kędziora
Journal:  Redox Rep       Date:  2011       Impact factor: 4.412

Review 5.  The role of comorbidities in cardioprotection.

Authors:  Michael N Sack; Elizabeth Murphy
Journal:  J Cardiovasc Pharmacol Ther       Date:  2011 Sep-Dec       Impact factor: 2.457

6.  Incident heart failure in relation to vascular disease: insights from the Health, Aging, and Body Composition Study.

Authors:  Hassan Khan; Andreas P Kalogeropoulos; Faiez Zannad; Catherine N Marti; Peter W F Wilson; Vasiliki V Georgiopoulou; Alka M Kanaya; Anne B Newman; Erik Schelbert; Tamara B Harris; Stephen Kritchevsky; Clyde Yancy; Mihai Gheorghiade; Gregg C Fonarow; Javed Butler
Journal:  Eur J Heart Fail       Date:  2014-02-27       Impact factor: 15.534

7.  Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol.

Authors:  Angana G Rajapakse; Gautham Yepuri; João M Carvas; Sokrates Stein; Christian M Matter; Isabelle Scerri; Jean Ruffieux; Jean-Pierre Montani; Xiu-Fen Ming; Zhihong Yang
Journal:  PLoS One       Date:  2011-04-22       Impact factor: 3.240

Review 8.  Oxidative stress in aging--matters of the heart and mind.

Authors:  Krishnan Venkataraman; Sandhya Khurana; T C Tai
Journal:  Int J Mol Sci       Date:  2013-09-02       Impact factor: 5.923

9.  Oral sapropterin augments reflex vasoconstriction in aged human skin through noradrenergic mechanisms.

Authors:  Anna E Stanhewicz; Lacy M Alexander; W Larry Kenney
Journal:  J Appl Physiol (1985)       Date:  2013-07-18

Review 10.  The Aging Vasculature: Glucose Tolerance, Hypoglycemia and the Role of the Serum Response Factor.

Authors:  Hazel Aberdeen; Kaela Battles; Ariana Taylor; Jeranae Garner-Donald; Ana Davis-Wilson; Bryan T Rogers; Candice Cavalier; Emmanuel D Williams
Journal:  J Cardiovasc Dev Dis       Date:  2021-05-17
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