BACKGROUND: The conventional calcium correction formula (corrected total calcium (mmol/L) = TCa (mmol/L) + 0.02 [40 (g/L) - albumin (g/L)]) is broadly applied for the estimation of serum calcium in haemodialysis (HD) patients, despite the fact that it was not derived or validated in a HD population. A novel formula was derived and validated for corrected serum calcium in HD patients. METHODS: Total calcium (TCa), ionized calcium (iCa(2+)), magnesium, phosphate, albumin and bicarbonate were collected from 60 HD patients to derive the formula. A validation set of 237 stable HD patients was then examined, and subjects were classified as hyper-, hypo- and normocalcaemic based on the iCa(2+). Agreement of the new formula was calculated with iCa(2+) as the gold standard, using the intraclass correlation coefficient (ICC). This was compared to the agreement between iCa(2+) and the following: uncorrected total serum calcium (TCa), the conventional correction formula, the Orrell formula and the Clase formula. RESULTS: Using multiple linear regression the following formula was derived: corrected total calcium (mmol/L) = TCa (mmol/L) + 0.01 [30 (g/L) - albumin (g/L)]. The new formula had superior agreement compared to all of the other formulae. There was a statistically significant greater agreement between the new formula and the iCa(2+) as compared to the conventional formula (P < 0.01). However, the new formula did not significantly outperform the Orrell formula, the Clase formula or Total calcium. CONCLUSIONS: The use of our simple new formula should enable more appropriate decision making compared to the conventional formula in the highly complex HD population.
BACKGROUND: The conventional calcium correction formula (corrected total calcium (mmol/L) = TCa (mmol/L) + 0.02 [40 (g/L) - albumin (g/L)]) is broadly applied for the estimation of serum calcium in haemodialysis (HD) patients, despite the fact that it was not derived or validated in a HD population. A novel formula was derived and validated for corrected serum calcium in HDpatients. METHODS: Total calcium (TCa), ionizedcalcium (iCa(2+)), magnesium, phosphate, albumin and bicarbonate were collected from 60 HDpatients to derive the formula. A validation set of 237 stable HDpatients was then examined, and subjects were classified as hyper-, hypo- and normocalcaemic based on the iCa(2+). Agreement of the new formula was calculated with iCa(2+) as the gold standard, using the intraclass correlation coefficient (ICC). This was compared to the agreement between iCa(2+) and the following: uncorrected total serum calcium (TCa), the conventional correction formula, the Orrell formula and the Clase formula. RESULTS: Using multiple linear regression the following formula was derived: corrected total calcium (mmol/L) = TCa (mmol/L) + 0.01 [30 (g/L) - albumin (g/L)]. The new formula had superior agreement compared to all of the other formulae. There was a statistically significant greater agreement between the new formula and the iCa(2+) as compared to the conventional formula (P < 0.01). However, the new formula did not significantly outperform the Orrell formula, the Clase formula or Total calcium. CONCLUSIONS: The use of our simple new formula should enable more appropriate decision making compared to the conventional formula in the highly complex HD population.
Authors: Sadeq A Quraishi; Edward A Bittner; Livnat Blum; Caitlin M McCarthy; Ishir Bhan; Carlos A Camargo Journal: Crit Care Med Date: 2014-06 Impact factor: 7.598
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Authors: Maria Luger; Renate Kruschitz; Christian Kienbacher; Stefan Traussnigg; Felix B Langer; Karin Schindler; Tanja Würger; Friedrich Wrba; Michael Trauner; Gerhard Prager; Bernhard Ludvik Journal: Obes Surg Date: 2016-10 Impact factor: 4.129
Authors: Maria Luger; Renate Kruschitz; Christian Kienbacher; Stefan Traussnigg; Felix B Langer; Gerhard Prager; Karin Schindler; Enikö Kallay; Friedrich Hoppichler; Michael Trauner; Michael Krebs; Rodrig Marculescu; Bernhard Ludvik Journal: Obes Surg Date: 2017-05 Impact factor: 4.129
Authors: Nathaniel Lee; Laura V White; Flora P Marin; Naomi R Saludar; Marietta B Solante; Rosario J C Tactacan-Abrenica; Rugaiya W Calapis; Motoi Suzuki; Nobuo Saito; Koya Ariyoshi; Christopher M Parry; Tansy Edwards; Sharon E Cox Journal: PLoS One Date: 2019-06-27 Impact factor: 3.240