Relation of serum uric acid levels with the presence and severity of angiographic coronary artery disease.

The aim of this study is to investigate the association between uric acid level and severity of coronary artery disease. Consecutive 495 patients with coronary artery disease and 356 individuals with normal coronary angiograms were included in the study. Severity of coronary artery disease was evaluated using the Gensini score index. For both groups, conventional risk factors, the levels of uric acid, and other biochemical markers were assessed. The mean uric acid levels of the patient group were significantly higher than those of the control group (P = .002). Mean uric acid levels were higher in men than in women (P < .001). In the coronary artery disease group, there was no significant correlation between uric acid levels and Gensini score in both sexes. Thus, it can be concluded that uric acid level is associated with the presence but not with the severity of coronary artery disease.