Literature DB >> 18386155

Interaction between methotrexate and omeprazole in an adolescent with leukemia: a case report.

Tiene G M Bauters1, Joris Verlooy, Hugo Robays, Geneviéve Laureys.   

Abstract

We present a case of severe mucositis due to a drug-drug interaction between methotrexate (MTX) and omeprazole in an adolescent with Acute Lymphatic Leukemia (ALL). In view of the prevalence of MTX in many cytotoxic protocols, and the frequent use of omeprazole in the (ambulatory) oncology setting, we believe that this case-report is worth mentioning.

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Year:  2008        PMID： 18386155     DOI： 10.1007/s11096-008-9204-9

Source DB:  PubMed          Journal:  Pharm World Sci        ISSN： 0928-1231


  5 in total

1.  Omeprazole does not alter plasma methotrexate clearance.

Authors:  J Whelan; D Hoare; P Leonard
Journal:  Cancer Chemother Pharmacol       Date:  1999       Impact factor: 3.333

2.  Potential interaction between methotrexate and omeprazole.

Authors:  B Beorlegui; A Aldaz; A Ortega; I Aquerreta; L Sierrasesúmega; J Giráldez
Journal:  Ann Pharmacother       Date:  2000-09       Impact factor: 3.154

3.  High-dose methotrexate-doxycycline interaction.

Authors:  J J Tortajada-Ituren; J P Ordovás-Baines; P Llopis-Salvia; N V Jiménez-Torres
Journal:  Ann Pharmacother       Date:  1999 Jul-Aug       Impact factor: 3.154

4.  Optimal management of methotrexate intoxication in a child with osteosarcoma.

Authors:  Hélène Peyriere; Marylène Cociglio; Geneviève Margueritte; Catherine Vallat; Jean-Pierre Blayac; Dominique Hillaire-Buys
Journal:  Ann Pharmacother       Date:  2004-01-23       Impact factor: 3.154

5.  Impact of omeprazole on the plasma clearance of methotrexate.

Authors:  T Reid; A Yuen; M Catolico; R W Carlson
Journal:  Cancer Chemother Pharmacol       Date:  1993       Impact factor: 3.333
  5 in total
  9 in total

1.  Potential drug-drug interactions between anti-cancer agents and community pharmacy dispensed drugs.

Authors:  Marsha L Voll; Kim D Yap; Wim E Terpstra; Mirjam Crul
Journal:  Pharm World Sci       Date:  2010-07-20

Review 2.  Accumulating evidence for a drug-drug interaction between methotrexate and proton pump inhibitors.

Authors:  Shewit Bezabeh; Ann Corken Mackey; Paul Kluetz; Dilara Jappar; Joyce Korvick
Journal:  Oncologist       Date:  2012-04-03

Review 3.  Effect of proton pump inhibitors on high-dose methotrexate elimination: a systematic review and meta-analysis.

Authors:  Xi Wang; Yanqin Song; Jingjing Wang; Jin He; Ruming Liu; Xiaosu Li; Hua Huang; Jun Zhang
Journal:  Int J Clin Pharm       Date:  2020-01-08

Review 4.  Drug-drug interaction profiles of proton pump inhibitors.

Authors:  Ryuichi Ogawa; Hirotoshi Echizen
Journal:  Clin Pharmacokinet       Date:  2010-08       Impact factor: 6.447

5.  Retrospective evaluation of methotrexate elimination when co-administered with proton pump inhibitors.

Authors:  David J Reeves; Elizabeth S Moore; Devon Bascom; Brandon Rensing
Journal:  Br J Clin Pharmacol       Date:  2014-09       Impact factor: 4.335

6.  Pharmacokinetic drug interaction profile of omeprazole with adverse consequences and clinical risk management.

Authors:  Wei Li; Su Zeng; Lu-Shan Yu; Quan Zhou
Journal:  Ther Clin Risk Manag       Date:  2013-05-27       Impact factor: 2.423

Review 7.  Non-infectious chemotherapy-associated acute toxicities during childhood acute lymphoblastic leukemia therapy.

Authors:  Kjeld Schmiegelow; Klaus Müller; Signe Sloth Mogensen; Pernille Rudebeck Mogensen; Benjamin Ole Wolthers; Ulrik Kristoffer Stoltze; Ruta Tuckuviene; Thomas Frandsen
Journal:  F1000Res       Date:  2017-04-07

Review 8.  Proton Pump Inhibitors and Oncologic Treatment Efficacy: A Practical Review of the Literature for Oncologists.

Authors:  Angel A T Uchiyama; Pedro A I A Silva; Moisés S M Lopes; Cheng T Yen; Eliza D Ricardo; Taciana Mutão; Jefferson R Pimenta; Larissa M Machado; Denis S Shimba; Renata D Peixoto
Journal:  Curr Oncol       Date:  2021-02-03       Impact factor: 3.677

9.  Consensus Guideline for Use of Glucarpidase in Patients with High-Dose Methotrexate Induced Acute Kidney Injury and Delayed Methotrexate Clearance.

Authors:  Laura B Ramsey; Frank M Balis; Maureen M O'Brien; Kjeld Schmiegelow; Jennifer L Pauley; Archie Bleyer; Brigitte C Widemann; David Askenazi; Sharon Bergeron; Anushree Shirali; Stefan Schwartz; Alexander A Vinks; Jesper Heldrup
Journal:  Oncologist       Date:  2017-10-27
  9 in total

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