Literature DB >> 18385345

Dihydroartemisinin-piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: a preliminary report.

Marcus J Rijken1, Rose McGready, Machteld E Boel, Marion Barends, Stephane Proux, Mupawjay Pimanpanarak, Pratap Singhasivanon, François Nosten.   

Abstract

Dihydroartemisinin-piperaquine (DHA-PPQ) is a promising new artemisinin combination treatment. There are no published data on the intentional use of the drug in pregnancy. Between June 2006 and January 2007, 50 Karen pregnant women with recurrent P. falciparum infections, despite 7-day treatments with quinine or artesunate (+/-clindamycin) or both, were treated with DHA-PPQ. This rescue treatment was effective and well tolerated and there was no evidence of toxicity for the mothers or the fetus. The PCR adjusted cure rate by Kaplan Meier analysis at day 63 was 92.2% (95% CI: 76.9-97.4).

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Year:  2008        PMID： 18385345

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  26 in total

Review 1.  Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria.

Authors:  Richard T Eastman; David A Fidock
Journal:  Nat Rev Microbiol       Date:  2009-11-02       Impact factor: 60.633

2.  Pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated falciparum malaria.

Authors:  Marcus J Rijken; Rose McGready; Aung Phae Phyo; Niklas Lindegardh; Joel Tarning; Natthapon Laochan; Hla Hla Than; Oh Mu; Aye Kyi Win; Pratap Singhasivanon; Nicholas White; François Nosten
Journal:  Antimicrob Agents Chemother       Date:  2011-09-26       Impact factor: 5.191

3.  Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites.

Authors:  Richard T Eastman; Neekesh V Dharia; Elizabeth A Winzeler; David A Fidock
Journal:  Antimicrob Agents Chemother       Date:  2011-05-16       Impact factor: 5.191

4.  Dihydroartemisinin-Piperaquine for the Prevention of Malaria in Pregnancy.

Authors:  Abel Kakuru; Prasanna Jagannathan; Mary K Muhindo; Paul Natureeba; Patricia Awori; Miriam Nakalembe; Bishop Opira; Peter Olwoch; John Ategeka; Patience Nayebare; Tamara D Clark; Margaret E Feeney; Edwin D Charlebois; Gabrielle Rizzuto; Atis Muehlenbachs; Diane V Havlir; Moses R Kamya; Grant Dorsey
Journal:  N Engl J Med       Date:  2016-03-10       Impact factor: 91.245

5.  Intermittent Preventive Treatment With Dihydroartemisinin-Piperaquine for the Prevention of Malaria Among HIV-Infected Pregnant Women.

Authors:  Paul Natureeba; Abel Kakuru; Mary Muhindo; Teddy Ochieng; John Ategeka; Catherine A Koss; Albert Plenty; Edwin D Charlebois; Tamara D Clark; Bridget Nzarubara; Miriam Nakalembe; Deborah Cohan; Gabrielle Rizzuto; Atis Muehlenbachs; Theodore Ruel; Prasanna Jagannathan; Diane V Havlir; Moses R Kamya; Grant Dorsey
Journal:  J Infect Dis       Date:  2017-07-01       Impact factor: 5.226

Review 6.  Tissue Parasites in HIV Infection.

Authors:  Eva H Clark; Jose A Serpa
Journal:  Curr Infect Dis Rep       Date:  2019-11-16       Impact factor: 3.725

Review 7.  Dihydroartemisinin/Piperaquine: a review of its use in the treatment of uncomplicated Plasmodium falciparum malaria.

Authors:  Gillian M Keating
Journal:  Drugs       Date:  2012-05-07       Impact factor: 9.546

8.  A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern Laos.

Authors:  Mayfong Mayxay; Sommay Keomany; Maniphone Khanthavong; Phoutthalavanh Souvannasing; Kasia Stepniewska; Tiengthong Khomthilath; Siamphay Keola; Tiengkham Pongvongsa; Samlane Phompida; David Ubben; Neena Valecha; Nicholas J White; Paul N Newton
Journal:  Am J Trop Med Hyg       Date:  2010-12       Impact factor: 2.345

9.  Piperaquine pharmacodynamics and parasite viability in a murine malaria model.

Authors:  Brioni R Moore; Kenneth F Ilett; Madhu Page-Sharp; Jeffrey D Jago; Kevin T Batty
Journal:  Antimicrob Agents Chemother       Date:  2009-04-20       Impact factor: 5.191

10.  Safety, tolerability and pharmacokinetic properties of coadministered azithromycin and piperaquine in pregnant Papua New Guinean women.

Authors:  Brioni R Moore; John M Benjamin; Siu On Auyeung; Sam Salman; Gumul Yadi; Suzanne Griffin; Madhu Page-Sharp; Kevin T Batty; Peter M Siba; Ivo Mueller; Stephen J Rogerson; Timothy Me Davis
Journal:  Br J Clin Pharmacol       Date:  2016-03-27       Impact factor: 4.335
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