Literature DB >> 18385245

Transformation by bovine papillomavirus type 1 E6 requires paxillin.

Ramon Wade1, Nicole Brimer, Scott Vande Pol.   

Abstract

Papillomavirus E6 proteins are adapters that change the function of cellular regulatory proteins. The bovine papillomavirus type 1 E6 (BE6) binds to LXXLL peptide sequences termed LD motifs (consensus sequence LDXLLXXL) on the cellular protein paxillin that is a substrate of Src and focal adhesion kinases. Anchorage-independent transformation induced by BE6 required both paxillin and BE6-binding LD motifs on paxillin but was independent of the major tyrosine phosphorylation sites of paxillin. The essential role of paxillin in transformation by BE6 highlights the role of paxillin in the transduction of cellular signals that result in anchorage-independent cell proliferation.

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Year:  2008        PMID： 18385245      PMCID： PMC2395150          DOI： 10.1128/JVI.02747-07

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  35 in total

Review 1.  Actin, microtubules and focal adhesion dynamics during cell migration.

Authors:  Bernhard Wehrle-Haller; Beat A Imhof
Journal:  Int J Biochem Cell Biol       Date:  2003-01       Impact factor: 5.085

Review 2.  Illuminating adhesion complexes in migrating cells: moving toward a bright future.

Authors:  Donna J Webb; Claire M Brown; Alan F Horwitz
Journal:  Curr Opin Cell Biol       Date:  2003-10       Impact factor: 8.382

3.  Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions.

Authors:  S N Nikolopoulos; C E Turner
Journal:  J Biol Chem       Date:  2001-04-13       Impact factor: 5.157

4.  Identification of a second transforming function in bovine papillomavirus type 1 E6 and the role of E6 interactions with paxillin, E6BP, and E6AP.

Authors:  K Das; J Bohl; S B Vande Pol
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

5.  Paxillin null embryonic stem cells are impaired in cell spreading and tyrosine phosphorylation of focal adhesion kinase.

Authors:  Ramon Wade; Joanna Bohl; Scott Vande Pol
Journal:  Oncogene       Date:  2002-01-03       Impact factor: 9.867

6.  The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling.

Authors:  Margit Hagel; Elizabeth L George; Ann Kim; Rulla Tamimi; Sarah L Opitz; Christopher E Turner; Akira Imamoto; Sheila M Thomas
Journal:  Mol Cell Biol       Date:  2002-02       Impact factor: 4.272

7.  Cooperative transformation and coexpression of bovine papillomavirus type 1 E5 and E7 proteins.

Authors:  J Bohl; B Hull; S B Vande Pol
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

8.  Degradation of focal adhesion proteins paxillin and p130cas by caspases or calpains in apoptotic rat-1 and L929 cells.

Authors:  S R Shim; S Kook; J I Kim; W K Song
Journal:  Biochem Biophys Res Commun       Date:  2001-08-24       Impact factor: 3.575

9.  Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion.

Authors:  S N Nikolopoulos; C E Turner
Journal:  J Cell Biol       Date:  2000-12-25       Impact factor: 10.539

10.  Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin.

Authors:  S M Thomas; M Hagel; C E Turner
Journal:  J Cell Sci       Date:  1999-01       Impact factor: 5.285
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  13 in total

Review 1.  Papillomavirus E6 oncoproteins.

Authors:  Scott B Vande Pol; Aloysius J Klingelhutz
Journal:  Virology       Date:  2013-05-24       Impact factor: 3.616

Review 2.  Manipulation of Focal Adhesion Signaling by Pathogenic Microbes.

Authors:  Korinn N Murphy; Amanda J Brinkworth
Journal:  Int J Mol Sci       Date:  2021-01-29       Impact factor: 5.923

3.  Paxillin enables attachment-independent tyrosine phosphorylation of focal adhesion kinase and transformation by RAS.

Authors:  Ramon Wade; Nicole Brimer; Charles Lyons; Scott Vande Pol
Journal:  J Biol Chem       Date:  2011-09-07       Impact factor: 5.157

4.  Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins.

Authors:  Katia Zanier; Sebastian Charbonnier; Abdellahi Ould M'hamed Ould Sidi; Alastair G McEwen; Maria Giovanna Ferrario; Pierre Poussin-Courmontagne; Vincent Cura; Nicole Brimer; Khaled Ould Babah; Tina Ansari; Isabelle Muller; Roland H Stote; Jean Cavarelli; Scott Vande Pol; Gilles Travé
Journal:  Science       Date:  2013-02-08       Impact factor: 47.728

5.  Interactions between E6, FAK, and GIT1 at paxillin LD4 are necessary for transformation by bovine papillomavirus 1 E6.

Authors:  Nicole Brimer; Ramon Wade; Scott Vande Pol
Journal:  J Virol       Date:  2014-06-18       Impact factor: 5.103

6.  Cutaneous papillomavirus E6 oncoproteins associate with MAML1 to repress transactivation and NOTCH signaling.

Authors:  N Brimer; C Lyons; A E Wallberg; S B Vande Pol
Journal:  Oncogene       Date:  2012-01-16       Impact factor: 9.867

Review 7.  Papillomavirus E6 Oncoproteins Take Common Structural Approaches to Solve Different Biological Problems.

Authors:  Scott Vande Pol
Journal:  PLoS Pathog       Date:  2015-10-15       Impact factor: 6.823

8.  Bovine papillomavirus clastogenic effect analyzed in comet assay.

Authors:  R P Araldi; T C Melo; N Diniz; J Mazzuchelli-de-Souza; R F Carvalho; W Beçak; R C Stocco
Journal:  Biomed Res Int       Date:  2013-07-15       Impact factor: 3.411

9.  Mutagenic Potential ofBos taurus Papillomavirus Type 1 E6 Recombinant Protein: First Description.

Authors:  Rodrigo Pinheiro Araldi; Jacqueline Mazzuchelli-de-Souza; Diego Grando Modolo; Edislane Barreiros de Souza; Thatiana Corrêa de Melo; Diva Denelle Spadacci-Morena; Roberta Fiusa Magnelli; Márcio Augusto Caldas Rocha de Carvalho; Paulo Luis de Sá Júnior; Rodrigo Franco de Carvalho; Willy Beçak; Rita de Cassia Stocco
Journal:  Biomed Res Int       Date:  2015-12-09       Impact factor: 3.411

10.  Association of papillomavirus E6 proteins with either MAML1 or E6AP clusters E6 proteins by structure, function, and evolutionary relatedness.

Authors:  Nicole Brimer; Camille M Drews; Scott B Vande Pol
Journal:  PLoS Pathog       Date:  2017-12-27       Impact factor: 6.823
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