Literature DB >> 18385136

Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects.

Stefano Costanzi1, Susanne Neumann, Marvin C Gershengorn.   

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Year:  2008        PMID： 18385136      PMCID： PMC2423253          DOI： 10.1074/jbc.R800014200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


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  35 in total

1.  Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists.

Authors:  Fengbin Song; Songfeng Lu; Joe Gunnet; Jun Z Xu; Pam Wines; Jef Proost; Yin Liang; Chris Baumann; Jim Lenhard; William V Murray; Keith T Demarest; Gee-Hong Kuo
Journal:  J Med Chem       Date:  2007-05-15       Impact factor: 7.446

2.  G protein-coupled receptors and insulin secretion: 119 and counting.

Authors:  S R Murthy Madiraju; Vincent Poitout
Journal:  Endocrinology       Date:  2007-06       Impact factor: 4.736

Review 3.  Fatty acid receptors as new therapeutic targets for diabetes.

Authors:  Geetha Vani Rayasam; Vamshi Krishna Tulasi; Joseph Alex Davis; Vinay S Bansal
Journal:  Expert Opin Ther Targets       Date:  2007-05       Impact factor: 6.902

4.  Identification of residues important for agonist recognition and activation in GPR40.

Authors:  Chi Shing Sum; Irina G Tikhonova; Susanne Neumann; Stanislav Engel; Bruce M Raaka; Stefano Costanzi; Marvin C Gershengorn
Journal:  J Biol Chem       Date:  2007-08-15       Impact factor: 5.157

Review 5.  Biology of incretins: GLP-1 and GIP.

Authors:  Laurie L Baggio; Daniel J Drucker
Journal:  Gastroenterology       Date:  2007-05       Impact factor: 22.682

Review 6.  GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity.

Authors:  H A Overton; M C T Fyfe; C Reynet
Journal:  Br J Pharmacol       Date:  2007-11-26       Impact factor: 8.739

Review 7.  The importance of free fatty acids in the development of Type 2 diabetes.

Authors:  J P H Wilding
Journal:  Diabet Med       Date:  2007-09       Impact factor: 4.359

8.  Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition.

Authors:  Irina G Tikhonova; Chi Shing Sum; Susanne Neumann; Craig J Thomas; Bruce M Raaka; Stefano Costanzi; Marvin C Gershengorn
Journal:  J Med Chem       Date:  2007-06-07       Impact factor: 7.446

9.  Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening.

Authors:  Irina G Tikhonova; Chi Shing Sum; Susanne Neumann; Stanislav Engel; Bruce M Raaka; Stefano Costanzi; Marvin C Gershengorn
Journal:  J Med Chem       Date:  2008-01-15       Impact factor: 7.446

Review 10.  G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes.

Authors:  Maria Sörhede Winzell; Bo Ahrén
Journal:  Pharmacol Ther       Date:  2007-08-29       Impact factor: 12.310
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  22 in total

1.  Linoleic acid induces migration and invasion through FFAR4- and PI3K-/Akt-dependent pathway in MDA-MB-231 breast cancer cells.

Authors:  Nathalia Serna-Marquez; Ricardo Diaz-Aragon; Emmanuel Reyes-Uribe; Pedro Cortes-Reynosa; Eduardo Perez Salazar
Journal:  Med Oncol       Date:  2017-04-29       Impact factor: 3.064

Review 2.  Why do anti-inflammatory therapies fail to improve insulin sensitivity?

Authors:  Zhan-guo Gao; Jian-ping Ye
Journal:  Acta Pharmacol Sin       Date:  2011-10-31       Impact factor: 6.150

3.  SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists.

Authors:  Dong-Oh Yoon; Xiaodi Zhao; Dohyun Son; Jung Tae Han; Jaesook Yun; Dongyun Shin; Hyun-Ju Park
Journal:  ACS Med Chem Lett       Date:  2017-11-21       Impact factor: 4.345

4.  Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish.

Authors:  Anjali K Nath; Junyan Ma; Zsu-Zsu Chen; Zhuyun Li; Maria Del Carmen Vitery; Michelle L Kelley; Randall T Peterson; Robert E Gerszten; Jing-Ruey J Yeh
Journal:  FASEB J       Date:  2019-12-02       Impact factor: 5.191

Review 5.  Regulation of energy balance by inflammation: common theme in physiology and pathology.

Authors:  Hui Wang; Jianping Ye
Journal:  Rev Endocr Metab Disord       Date:  2015-03       Impact factor: 6.514

6.  Discovery of 5-methyl-2-(4-((4-(methylsulfonyl)benzyl)oxy)phenyl)-4-(piperazin-1-yl)pyrimidine derivatives as novel GRP119 agonists for the treatment of diabetes and obesity.

Authors:  Jinying Chen; Zitai Sang; Lu Li; Linhong He; Liang Ma
Journal:  Mol Divers       Date:  2017-06-27       Impact factor: 2.943

7.  Docking-based virtual screening for ligands of G protein-coupled receptors: not only crystal structures but also in silico models.

Authors:  Santiago Vilar; Giulio Ferino; Sharangdhar S Phatak; Barkin Berk; Claudio N Cavasotto; Stefano Costanzi
Journal:  J Mol Graph Model       Date:  2010-11-19       Impact factor: 2.518

Review 8.  Regulation of energy metabolism by inflammation: a feedback response in obesity and calorie restriction.

Authors:  Jianping Ye; Jeffrey N Keller
Journal:  Aging (Albany NY)       Date:  2010-06       Impact factor: 5.682

Review 9.  Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3.

Authors:  Graeme Milligan; Leigh A Stoddart; Nicola J Smith
Journal:  Br J Pharmacol       Date:  2009-09       Impact factor: 8.739

10.  The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1.

Authors:  Nicola J Smith; Leigh A Stoddart; Nicola M Devine; Laura Jenkins; Graeme Milligan
Journal:  J Biol Chem       Date:  2009-04-27       Impact factor: 5.157
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