Literature DB >> 18384940

Hypoxia in microscopic tumors.

Xiao-Feng Li1, Joseph A O'Donoghue.   

Abstract

Tumor hypoxia has been commonly observed in a broad spectrum of primary solid malignancies. Hypoxia is associated with tumor progression, increased aggressiveness, enhanced metastatic potential and poor prognosis. Hypoxic tumor cells are resistant to radiotherapy and some forms of chemotherapy. Using an animal model, we recently showed that microscopic tumors less than 1mm diameter were severely hypoxic. In this review, models and techniques for the study of hypoxia in microscopic tumors are discussed.

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Year:  2008        PMID： 18384940      PMCID： PMC2460565          DOI： 10.1016/j.canlet.2008.02.037

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  71 in total

1.  Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker.

Authors:  J A Raleigh; D P Calkins-Adams; L H Rinker; C A Ballenger; M C Weissler; W C Fowler; D B Novotny; M A Varia
Journal:  Cancer Res       Date:  1998-09-01       Impact factor: 12.701

Review 2.  Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.

Authors:  Rakesh K Jain
Journal:  Science       Date:  2005-01-07       Impact factor: 47.728

3.  Identification of nonproliferating but viable hypoxic tumor cells in vivo.

Authors:  R E Durand; J A Raleigh
Journal:  Cancer Res       Date:  1998-08-15       Impact factor: 12.701

4.  Tumor vascularity, proliferation, and apoptosis in human melanoma micrometastases and macrometastases.

Authors:  R L Barnhill; M W Piepkorn; A J Cochran; E Flynn; T Karaoli; J Folkman
Journal:  Arch Dermatol       Date:  1998-08

5.  Characterization of carbonic anhydrase IX (CA IX) as an endogenous marker of chronic hypoxia in live human tumor cells.

Authors:  Dirk Vordermark; Anja Kaffer; Susanne Riedl; Astrid Katzer; Michael Flentje
Journal:  Int J Radiat Oncol Biol Phys       Date:  2005-03-15       Impact factor: 7.038

6.  Heterogeneity of tumor oxygenation: relationship to tumor necrosis, tumor size, and metastasis.

Authors:  K De Jaeger; F M Merlo; M C Kavanagh; A W Fyles; D Hedley; R P Hill
Journal:  Int J Radiat Oncol Biol Phys       Date:  1998-11-01       Impact factor: 7.038

7.  Vascular endothelial growth factor increased by pulmonary surgery accelerates the growth of micrometastases in metastatic lung cancer.

Authors:  Y Maniwa; M Okada; N Ishii; K Kiyooka
Journal:  Chest       Date:  1998-12       Impact factor: 9.410

8.  Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors.

Authors:  J A Raleigh; S C Chou; G E Arteel; M R Horsman
Journal:  Radiat Res       Date:  1999-05       Impact factor: 2.841

9.  Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling.

Authors:  J A Aguirre Ghiso; K Kovalski; L Ossowski
Journal:  J Cell Biol       Date:  1999-10-04       Impact factor: 10.539

10.  Evaluation of hypoxia in an experimental rat tumour model by [(18)F]fluoromisonidazole PET and immunohistochemistry.

Authors:  L Dubois; W Landuyt; K Haustermans; P Dupont; G Bormans; P Vermaelen; P Flamen; E Verbeken; L Mortelmans
Journal:  Br J Cancer       Date:  2004-11-29       Impact factor: 7.640
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  31 in total

1.  High 18F-FDG uptake in microscopic peritoneal tumors requires physiologic hypoxia.

Authors:  Xiao-Feng Li; Yuanyuan Ma; Xiaorong Sun; John L Humm; C Clifton Ling; Joseph A O'Donoghue
Journal:  J Nucl Med       Date:  2010-04       Impact factor: 10.057

2.  Hematopoietic stem cell niche is a potential therapeutic target for bone metastatic tumors.

Authors:  Yusuke Shiozawa; Kenneth J Pienta; Russell S Taichman
Journal:  Clin Cancer Res       Date:  2011-06-15       Impact factor: 12.531

3.  TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules.

Authors:  Qian Liu; Jessica D Sun; Jingli Wang; Dharmendra Ahluwalia; Amanda F Baker; Lee D Cranmer; Damien Ferraro; Yan Wang; Jian-Xin Duan; W Steve Ammons; John G Curd; Mark D Matteucci; Charles P Hart
Journal:  Cancer Chemother Pharmacol       Date:  2012-03-02       Impact factor: 3.333

4.  Highly Specific and Sensitive Fluorescent Nanoprobes for Image-Guided Resection of Sub-Millimeter Peritoneal Tumors.

Authors:  Aaron H Colby; Samantha M Berry; Ann M Moran; Kristine Amber Pasion; Rong Liu; Yolonda L Colson; Nelson Ruiz-Opazo; Mark W Grinstaff; Victoria L M Herrera
Journal:  ACS Nano       Date:  2017-02-01       Impact factor: 15.881

5.  Down-regulation of MutS homolog 3 by hypoxia in human colorectal cancer.

Authors:  Jie Li; Junichi Koike; Hiroyuki Kugoh; Michitsune Arita; Takahito Ohhira; Yoshinori Kikuchi; Kimihiko Funahashi; Ken Takamatsu; C Richard Boland; Minoru Koi; Hiromichi Hemmi
Journal:  Biochim Biophys Acta       Date:  2012-02-09

Review 6.  Endothelial Cell Metabolism.

Authors:  Guy Eelen; Pauline de Zeeuw; Lucas Treps; Ulrike Harjes; Brian W Wong; Peter Carmeliet
Journal:  Physiol Rev       Date:  2018-01-01       Impact factor: 37.312

7.  Combined Injection of (18)F-Fluorodeoxyglucose and 3'-Deoxy-3'-[(18)F]fluorothymidine PET Achieves More Complete Identification of Viable Lung Cancer Cells in Mice and Patients than Individual Radiopharmaceutical: A Proof-of-Concept Study.

Authors:  Xiao-Feng Li; Tao Huang; Huijie Jiang; Xuemei Wang; Baozhong Shen; Xiangcheng Wang; Chin K Ng; Gregory C Postel; A Cahid Civelek
Journal:  Transl Oncol       Date:  2013-12-01       Impact factor: 4.243

8.  (18)F-misonidazole PET imaging of hypoxia in micrometastases and macroscopic xenografts of human non-small cell lung cancer: a correlation with autoradiography and histological findings.

Authors:  Tao Huang; A Cahid Civelek; Huaiyu Zheng; Chin K Ng; Xiaoxian Duan; Junling Li; Gregory C Postel; Baozhong Shen; Xiao-Feng Li
Journal:  Am J Nucl Med Mol Imaging       Date:  2013-03-08

Review 9.  Nanoparticle drug-delivery systems for peritoneal cancers: a case study of the design, characterization and development of the expansile nanoparticle.

Authors:  Aaron H Colby; Nicholas H Oberlies; Cedric J Pearce; Victoria L M Herrera; Yolonda L Colson; Mark W Grinstaff
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2017-02-09

10.  Detection of hypoxia in microscopic tumors using 131I-labeled iodo-azomycin galactopyranoside (131I-IAZGP) digital autoradiography.

Authors:  Xiao-Feng Li; Xiaorong Sun; Yuanyuan Ma; Makiko Suehiro; Mutian Zhang; James Russell; John L Humm; C Clifton Ling; Joseph A O'Donoghue
Journal:  Eur J Nucl Med Mol Imaging       Date:  2009-11-17       Impact factor: 9.236
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