Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Steroid-induced sexual differentiation of the developing brain: multiple pathways, one goal.

Literature DB >> 18384643

Steroid-induced sexual differentiation of the developing brain: multiple pathways, one goal.

Abstract

Hormone exposure, including testosterone and its metabolite estradiol, induces a myriad of effects during a critical period of brain development that are necessary for brain sexual differentiation. Nuclear volume, neuronal morphology, and astrocyte complexity are examples of the wide range of effects by which testosterone and estradiol can induce permanent changes in the function of neurons for the purpose of reproduction in adulthood. This review will examine the multitude of mechanisms by which steroid hormones induce these permanent changes in brain structure and function. Elucidating how steroids alter brain development sheds light on how individual variation in neuronal phenotype is established during a critical period.

Entities: Chemical Disease

Mesh：

Substances：
Steroids

Year: 2008 PMID： 18384643 PMCID： PMC2565863 DOI： 10.1111/j.1471-4159.2008.05384.x

Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372

111 in total

Review 1. Astrocyte-induced modulation of synaptic transmission.

Authors: A Araque; R P Sanzgiri; V Parpura; P G Haydon
Journal: Can J Physiol Pharmacol Date: 1999-09 Impact factor: 2.273

2. Development of sex differences in the principal nucleus of the bed nucleus of the stria terminalis of mice: role of Bax-dependent cell death.

Authors: Tina Gotsiridze; Ningdong Kang; Dena Jacob; Nancy G Forger
Journal: Dev Neurobiol Date: 2007-02-15 Impact factor: 3.964

3. Survival of reproductive behaviors in estrogen receptor beta gene-deficient (betaERKO) male and female mice.

Authors: S Ogawa; J Chan; A E Chester; J A Gustafsson; K S Korach; D W Pfaff
Journal: Proc Natl Acad Sci U S A Date: 1999-10-26 Impact factor: 11.205

4. Morphological changes in the brains of adult male rats after neonatal castration.

Authors: D W Pfaff
Journal: J Endocrinol Date: 1966-12 Impact factor: 4.286

5. Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction.

Authors: Guofa Liu; Hilary Beggs; Claudia Jürgensen; Hwan-Tae Park; Hao Tang; Jessica Gorski; Kevin R Jones; Louis F Reichardt; Jane Wu; Yi Rao
Journal: Nat Neurosci Date: 2004-10-17 Impact factor: 24.884

6. Activation of FAK and Src are receptor-proximal events required for netrin signaling.

Authors: Weiquan Li; Jeeyong Lee; Haris G Vikis; Seung-Hee Lee; Guofa Liu; Jennifer Aurandt; Tang-Long Shen; Eric R Fearon; Jun-Lin Guan; Min Han; Yi Rao; Kyonsoo Hong; Kun-Liang Guan
Journal: Nat Neurosci Date: 2004-10-17 Impact factor: 24.884

7. Evidence for a morphological sex difference within the medial preoptic area of the rat brain.

Authors: R A Gorski; J H Gordon; J E Shryne; A M Southam
Journal: Brain Res Date: 1978-06-16 Impact factor: 3.252

Review 8. The neural basis of puberty and adolescence.

Authors: Cheryl L Sisk; Douglas L Foster
Journal: Nat Neurosci Date: 2004-10 Impact factor: 24.884

9. Involvement of the ventromedial and anterior hypothalamic nuclei in the hormonal induction of receptivity in the female rat.

Authors: D Mathews; D A Edwards
Journal: Physiol Behav Date: 1977-08

10. Glutamate AMPA/kainate receptors, not GABA(A) receptors, mediate estradiol-induced sex differences in the hypothalamus.

Authors: Brigitte J Todd; Jaclyn M Schwarz; Jessica A Mong; Margaret M McCarthy
Journal: Dev Neurobiol Date: 2007-02-15 Impact factor: 3.964

30 in total

Review 1. Sex differences in feeding behavior in rats: the relationship with neuronal activation in the hypothalamus.

Authors: Atsushi Fukushima; Hiroko Hagiwara; Hitomi Fujioka; Fukuko Kimura; Tatsuo Akema; Toshiya Funabashi
Journal: Front Neurosci Date: 2015-03-30 Impact factor: 4.677

2. Maternal deprivation and adolescent cannabinoid exposure impact hippocampal astrocytes, CB1 receptors and brain-derived neurotrophic factor in a sexually dimorphic fashion.

Authors: M López-Gallardo; A B López-Rodríguez; Á Llorente-Berzal; D Rotllant; K Mackie; A Armario; R Nadal; M-P Viveros
Journal: Neuroscience Date: 2011-10-06 Impact factor: 3.590

3. Sexual patterns and protogynous sex reversal in the rusty parrotfish, Scarus ferrugineus (Scaridae): histological and physiological studies.

Authors: El-Sayedah H Abdel-Aziz; Fayzah A Bawazeer; Tamer El-Sayed Ali; Mashael Al-Otaibi
Journal: Fish Physiol Biochem Date: 2012-02-05 Impact factor: 2.794

Steroid-induced sexual differentiation of the developing brain: multiple pathways, one goal.

Review 1. Astrocyte-induced modulation of synaptic transmission.

2. Development of sex differences in the principal nucleus of the bed nucleus of the stria terminalis of mice: role of Bax-dependent cell death.

3. Survival of reproductive behaviors in estrogen receptor beta gene-deficient (betaERKO) male and female mice.

4. Morphological changes in the brains of adult male rats after neonatal castration.

5. Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction.

6. Activation of FAK and Src are receptor-proximal events required for netrin signaling.

7. Evidence for a morphological sex difference within the medial preoptic area of the rat brain.

Review 8. The neural basis of puberty and adolescence.

9. Involvement of the ventromedial and anterior hypothalamic nuclei in the hormonal induction of receptivity in the female rat.

10. Glutamate AMPA/kainate receptors, not GABA(A) receptors, mediate estradiol-induced sex differences in the hypothalamus.

Review 1. Sex differences in feeding behavior in rats: the relationship with neuronal activation in the hypothalamus.

2. Maternal deprivation and adolescent cannabinoid exposure impact hippocampal astrocytes, CB1 receptors and brain-derived neurotrophic factor in a sexually dimorphic fashion.

3. Sexual patterns and protogynous sex reversal in the rusty parrotfish, Scarus ferrugineus (Scaridae): histological and physiological studies.

Review 4. Neuroendocrine targets of endocrine disruptors.

Review 5. Sexual differentiation of the brain and ADHD: what is a sex difference in prevalence telling us?

6. Sex differences in microglial colonization of the developing rat brain.

7. Working memory performance is reduced in children with congenital adrenal hyperplasia.

Review 8. Sexual differentiation of the brain in man and animals: of relevance to Klinefelter syndrome?

Review 9. The two faces of estradiol: effects on the developing brain.

10. Steroidogenic enzyme gene expression in the brain of the parthenogenetic whiptail lizard, Cnemidophorus uniparens.