Literature DB >> 18384261

Helicos BioSciences.

Patrice Milos1.   

Abstract

Helicos BioSciences Corporation is a life sciences company developing revolutionary new single molecule sequencing technology to provide the path to the US$1000 genome. True Single Molecule Sequencing (tSMS) will drive advancements in pharmacogenomics that can enable a better understanding of an individual's susceptibility to disease, develop more effective disease diagnoses and differentiate response to disease therapies. During 2007, genome-wide disease-association studies, the encylopedia of DNA elements (ENCODE) and the published genome sequence of two individuals have revealed human genome variation far more extensive than originally believed. These also demonstrated that common variations explain only a fraction of the genetic basis of disease. Therefore, the capability to understand an individual genome is critical in setting the foundation for the next great revolution in healthcare. Helicos is committed to this vision and will provide cost-effective genome sequencing and comprehensive analysis of the transcribed genome that can unlock the era of personalized healthcare.

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Mesh:

Year:  2008        PMID: 18384261     DOI: 10.2217/14622416.9.4.477

Source DB:  PubMed          Journal:  Pharmacogenomics        ISSN: 1462-2416            Impact factor:   2.533


  10 in total

1.  Mapping the regulon of Vibrio cholerae ferric uptake regulator expands its known network of gene regulation.

Authors:  Bryan W Davies; Ryan W Bogard; John J Mekalanos
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-12       Impact factor: 11.205

Review 2.  Plant systems biology: insights, advances and challenges.

Authors:  Bhavisha P Sheth; Vrinda S Thaker
Journal:  Planta       Date:  2014-03-27       Impact factor: 4.116

Review 3.  Improving human forensics through advances in genetics, genomics and molecular biology.

Authors:  Manfred Kayser; Peter de Knijff
Journal:  Nat Rev Genet       Date:  2011-03       Impact factor: 53.242

Review 4.  Transcriptome and proteome research in veterinary science: what is possible and what questions can be asked?

Authors:  Robert Klopfleisch; Achim D Gruber
Journal:  ScientificWorldJournal       Date:  2012-01-04

Review 5.  Advances in omics and bioinformatics tools for systems analyses of plant functions.

Authors:  Keiichi Mochida; Kazuo Shinozaki
Journal:  Plant Cell Physiol       Date:  2011-12       Impact factor: 4.927

Review 6.  The A, C, G, and T of Genome Assembly.

Authors:  Bilal Wajid; Muhammad U Sohail; Ali R Ekti; Erchin Serpedin
Journal:  Biomed Res Int       Date:  2016-05-10       Impact factor: 3.411

7.  Reverse Genetics and High Throughput Sequencing Methodologies for Plant Functional Genomics.

Authors:  Anis Ben-Amar; Samia Daldoul; Götz M Reustle; Gabriele Krczal; Ahmed Mliki
Journal:  Curr Genomics       Date:  2016-12       Impact factor: 2.236

8.  Single molecule sequencing of the M13 virus genome without amplification.

Authors:  Luyang Zhao; Liwei Deng; Gailing Li; Huan Jin; Jinsen Cai; Huan Shang; Yan Li; Haomin Wu; Weibin Xu; Lidong Zeng; Renli Zhang; Huan Zhao; Ping Wu; Zhiliang Zhou; Jiao Zheng; Pierre Ezanno; Andrew X Yang; Qin Yan; Michael W Deem; Jiankui He
Journal:  PLoS One       Date:  2017-12-18       Impact factor: 3.240

Review 9.  Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers.

Authors:  Ekaterina Olkhov-Mitsel; Bharati Bapat
Journal:  Cancer Med       Date:  2012-09-14       Impact factor: 4.452

Review 10.  Translational genomics and multi-omics integrated approaches as a useful strategy for crop breeding.

Authors:  Hong-Kyu Choi
Journal:  Genes Genomics       Date:  2018-10-23       Impact factor: 1.839

  10 in total

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