BACKGROUND: Most patients with pancreatic adenocarcinoma are diagnosed with locally advanced (unresectable) or metastatic disease. The aim of this study was to investigate possible prognostic factors of survival in such patients. PATIENTS AND METHODS: Two hundred and fifteen patients were studied retrospectively. Twenty-four potential prognostic variables (demographics, clinical parameters, biochemical markers, treatment modality) were examined. RESULTS: Mean survival was 29.0 weeks. 21.9% survived more than 36 weeks. On multivariate analysis, 10 factors had an independent effect on survival: tumour localisation, metastasis, performance status, jaundice, weight loss, C reactive protein, CEA, CA 19-9, palliative surgery and chemotherapy. Patients managed only with palliative care had a hazard ratio of 8.94 versus those offered a combination of palliative surgery and chemotherapy. CONCLUSION: Many factors could be used as predictors of survival in patients with advanced or metastatic pancreatic cancer. Chemotherapy and palliative surgery are associated with increased survival, and should be offered to all eligible patients.
BACKGROUND: Most patients with pancreatic adenocarcinoma are diagnosed with locally advanced (unresectable) or metastatic disease. The aim of this study was to investigate possible prognostic factors of survival in such patients. PATIENTS AND METHODS: Two hundred and fifteen patients were studied retrospectively. Twenty-four potential prognostic variables (demographics, clinical parameters, biochemical markers, treatment modality) were examined. RESULTS: Mean survival was 29.0 weeks. 21.9% survived more than 36 weeks. On multivariate analysis, 10 factors had an independent effect on survival: tumour localisation, metastasis, performance status, jaundice, weight loss, C reactive protein, CEA, CA 19-9, palliative surgery and chemotherapy. Patients managed only with palliative care had a hazard ratio of 8.94 versus those offered a combination of palliative surgery and chemotherapy. CONCLUSION: Many factors could be used as predictors of survival in patients with advanced or metastatic pancreatic cancer. Chemotherapy and palliative surgery are associated with increased survival, and should be offered to all eligible patients.
Authors: Laura Nemer; Somashekar G Krishna; Zarine K Shah; Darwin L Conwell; Zobeida Cruz-Monserrate; Mary Dillhoff; Denis C Guttridge; Alice Hinton; Andrei Manilchuk; Timothy M Pawlik; Carl R Schmidt; Erin E Talbert; Tanios Bekaii-Saab; Phil A Hart Journal: Pancreas Date: 2017-10 Impact factor: 3.327
Authors: Chen Yuan; Vicente Morales-Oyarvide; Natalia Khalaf; Kimberly Perez; Fred K Tabung; Gloria Y F Ho; Charles Kooperberg; Aladdin H Shadyab; Lihong Qi; Peter Kraft; Howard D Sesso; Edward L Giovannucci; JoAnn E Manson; Meir J Stampfer; Kimmie Ng; Charles S Fuchs; Brian M Wolpin; Ana Babic Journal: J Natl Cancer Inst Date: 2021-09-04 Impact factor: 13.506