BACKGROUND: Metabolic abnormalities, including insulin resistance and increased leptin levels, were noted in patients with schizophrenia who had received antipsychotics. In this study, we examined the leptin levels of antipsychotic-naïve schizophrenic patients. METHOD: Seventeen antipsychotic-naïve patients with schizophrenia and 16 sex-, age- and body mass index (BMI)-matched subjects were recruited from the psychiatric outpatient clinic and community, respectively. Serum leptin levels of the healthy controls and antipsychotic-naïve patients were compared. The relationships between leptin level and gender, Positive and Negative Syndrome Scale score, and duration of illness were analyzed by Spearman's correlation. RESULTS: Compared with sex-, age- and BMI-matched subjects, the female schizophrenic patients had elevated serum leptin levels. In the male patients, the results of this preliminary study also revealed a positive correlation between leptin levels and the Aggression Risk Profile subscale of the PANSS. CONCLUSION: This preliminary study suggests possible gender-specific leptin dysregulation in antipsychotic-naïve schizophrenic patients. Copyright 2008 S. Karger AG, Basel.
BACKGROUND:Metabolic abnormalities, including insulin resistance and increased leptin levels, were noted in patients with schizophrenia who had received antipsychotics. In this study, we examined the leptin levels of antipsychotic-naïve schizophrenicpatients. METHOD: Seventeen antipsychotic-naïve patients with schizophrenia and 16 sex-, age- and body mass index (BMI)-matched subjects were recruited from the psychiatricoutpatient clinic and community, respectively. Serum leptin levels of the healthy controls and antipsychotic-naïve patients were compared. The relationships between leptin level and gender, Positive and Negative Syndrome Scale score, and duration of illness were analyzed by Spearman's correlation. RESULTS: Compared with sex-, age- and BMI-matched subjects, the female schizophrenicpatients had elevated serum leptin levels. In the male patients, the results of this preliminary study also revealed a positive correlation between leptin levels and the Aggression Risk Profile subscale of the PANSS. CONCLUSION: This preliminary study suggests possible gender-specific leptin dysregulation in antipsychotic-naïve schizophrenicpatients. Copyright 2008 S. Karger AG, Basel.
Authors: S M Gohar; I Dieset; N E Steen; R H Mørch; T S J Vedal; E J Reponen; V M Steen; O A Andreassen; I Melle Journal: Acta Psychiatr Scand Date: 2019-03-18 Impact factor: 6.392