OBJECTIVE: To characterize postural stability control and levodopa responsiveness in early Parkinson's disease (PD). METHODS: Postural sway was studied during quiet stance in ten patients within six years of PD onset, both before (OFF) and after (ON) regular oral levodopa dosing. Postural sway was recorded using a force platform during 30 sec with eyes open, and six dependent variables were examined. RESULTS: Mild baseline subclinical changes in postural sway were recorded in our patients. Clear benefit was observed in five out of six characteristics (mean sway, transversal sway, sagittal sway, sway intensity, and sway area) in the ON condition. CONCLUSION: Postural control mechanisms are affected early in PD and modulated by dopamine.
OBJECTIVE: To characterize postural stability control and levodopa responsiveness in early Parkinson's disease (PD). METHODS: Postural sway was studied during quiet stance in ten patients within six years of PD onset, both before (OFF) and after (ON) regular oral levodopa dosing. Postural sway was recorded using a force platform during 30 sec with eyes open, and six dependent variables were examined. RESULTS: Mild baseline subclinical changes in postural sway were recorded in our patients. Clear benefit was observed in five out of six characteristics (mean sway, transversal sway, sagittal sway, sway intensity, and sway area) in the ON condition. CONCLUSION: Postural control mechanisms are affected early in PD and modulated by dopamine.
Authors: Martina Mancini; Fay B Horak; Cris Zampieri; Patricia Carlson-Kuhta; John G Nutt; Lorenzo Chiari Journal: Parkinsonism Relat Disord Date: 2011-06-08 Impact factor: 4.891
Authors: D Campbell Dewey; Svjetlana Miocinovic; Ira Bernstein; Pravin Khemani; Richard B Dewey; Ross Querry; Shilpa Chitnis; Richard B Dewey Journal: J Neurol Sci Date: 2014-07-19 Impact factor: 3.181
Authors: Digna de Kam; Jorik Nonnekes; Lars B Oude Nijhuis; Alexander C H Geurts; Bastiaan R Bloem; Vivian Weerdesteyn Journal: J Neurol Date: 2014-09-17 Impact factor: 4.849