Literature DB >> 18380276

Methylprednisolone for acute spinal cord injury: 5-year practice reversal.

R John Hurlbert1, Mark G Hamilton.   

Abstract

OBJECTIVE: To re-evaluate practice patterns for methylprednisolone (MP) administration in patients with acute spinal cord injury (SCI) within the spinal surgery community across Canada five years after the publication of practice recommendations.
METHODS: Canadian orthopedic and neurological spine surgeons were surveyed at their respective annual meetings about their practice of steroid administration for acute SCI by means of a questionnaire comprised of the same seven questions posed five years ago plus an additional question related to change of view.
RESULTS: Forty-two surgeons and twenty-one residents directly involved in the acute management of SCI completed the questionnaire. Seventy-six percent of spinal surgeons do not prescribe MP for SCI in sharp contrast to 76% who prescribed it five years ago. Of the 24% who use steroids, the NASCIS II dosing regimen is most commonly followed. One third of physicians continue to administer MP because of fear of litigation.
CONCLUSIONS: Over a five year period there has been a complete reversal in practice patterns of MP administration for SCI, along with an increased familiarity of the published literature. Attendance at meetings, participation in local group discussions, and peer-reviewed publications appear effective in altering practice preferences arising from peer pressure and even fear of litigation.

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Year:  2008        PMID: 18380276     DOI: 10.1017/s031716710000754x

Source DB:  PubMed          Journal:  Can J Neurol Sci        ISSN: 0317-1671            Impact factor:   2.104


  28 in total

1.  The PPAR alpha agonist gemfibrozil is an ineffective treatment for spinal cord injured mice.

Authors:  Akshata Almad; A Todd Lash; Ping Wei; Amy E Lovett-Racke; Dana M McTigue
Journal:  Exp Neurol       Date:  2011-09-21       Impact factor: 5.330

2.  Targeted modulation of the neuroinflammatory response after spinal cord injury: the ongoing quest for the "holy grail".

Authors:  Philip F Stahel; Michael A Flierl
Journal:  Am J Pathol       Date:  2010-10-15       Impact factor: 4.307

3.  Cochrane in CORR1: Steroids for Acute Spinal Cord Injury (Review).

Authors:  Nathan Evaniew; Marcel Dvorak
Journal:  Clin Orthop Relat Res       Date:  2016-01       Impact factor: 4.176

4.  The incomplete picture of incomplete spinal cord injury.

Authors:  Robert E Ayer; Farbod Asgarzadie
Journal:  Transl Stroke Res       Date:  2011-11-12       Impact factor: 6.829

Review 5.  Targeting microvasculature for neuroprotection after SCI.

Authors:  Janelle M Fassbender; Scott R Whittemore; Theo Hagg
Journal:  Neurotherapeutics       Date:  2011-04       Impact factor: 7.620

6.  Experimental Treatments for Spinal Cord Injury: What you Should Know.

Authors:  Vieri Failli; Naomi Kleitman; Daniel P Lammertse; Jane T C Hsieh; John D Steeves; James W Fawcett; Mark H Tuszynski; Armin Curt; Michael G Fehlings; James D Guest; Andrew R Blight
Journal:  Top Spinal Cord Inj Rehabil       Date:  2021

Review 7.  Early neurological care of patients with spinal cord injury.

Authors:  Thomas M Kessler; Luca R Traini; Blayne Welk; Marc P Schneider; Jeffrey Thavaseelan; Armin Curt
Journal:  World J Urol       Date:  2018-05-28       Impact factor: 4.226

8.  Rescuing vasculature with intravenous angiopoietin-1 and alpha v beta 3 integrin peptide is protective after spinal cord injury.

Authors:  Shu Han; Sheila A Arnold; Srinivas D Sithu; Edward T Mahoney; Justin T Geralds; Phuong Tran; Richard L Benton; Melissa A Maddie; Stanley E D'Souza; Scott R Whittemore; Theo Hagg
Journal:  Brain       Date:  2010-04       Impact factor: 13.501

9.  Presumptive fibrocartilaginous embolic myelopathy in a pot-bellied pig.

Authors:  Shannon Darby; Diego E Gomez; Kallie Hobbs; Sheila Carrera-Justiz; Federico Vilaplana Grosso; Robert MacKay
Journal:  Can Vet J       Date:  2021-02       Impact factor: 1.008

Review 10.  Cervical spine injuries in American football.

Authors:  Jeffrey A Rihn; David T Anderson; Kathleen Lamb; Peter F Deluca; Ahmed Bata; Paul A Marchetto; Nuno Neves; Alexander R Vaccaro
Journal:  Sports Med       Date:  2009       Impact factor: 11.136

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