Literature DB >> 18379895

Oral chemotherapy in paediatric oncology in the UK: problems, perceptions and information needs of parents.

Nanna Christiansen1, Kevin M G Taylor, Catherine Duggan.   

Abstract

OBJECTIVE: To identify problems, perceptions and information needs of parents and carers regarding oral chemotherapy.
SETTING: Two Paediatric Oncology Centres in the UK.
METHODS: A semi-structured questionnaire was developed in consultation with professionals working within paediatric oncology. Questionnaires were administered in face-to-face interviews with parents of patients attending clinic appointments. Responses to questions were coded and entered into a database for descriptive and inferential analyses. Responses to open questions were coded using simple thematic analysis whereby codes and themes emerged from the data and were compared and contrasted between respondents. Findings were further validated by quotes from interviewees to open questions. MAIN OUTCOME MEASURES: Awareness and knowledge of medicines, information needs and handling procedures.
RESULTS: Fifty-five interviews were conducted. Most interviewees viewed oral and intravenous chemotherapy as equally important and potent. Three-quarters of parents were aware of the adverse effects chemotherapy could have on them, worryingly three-quarters of the same group of parents did not use all the handling precaution methods advised by health care professionals. Knowledge of acute lymphoblastic leukaemia maintenance treatment was assessed in 47 interviewees; 31 parents were able to explain the reasons for maintenance chemotherapy. Interviewees felt well informed by the hospital and found it easy to access information they needed. The data suggest the majority of parents had a great interest in understanding the disease and treatment, with 91% using the internet to access further information. Three-quarters of parents faced some kind of difficulty when dealing with oral chemotherapy, including problems with the patient not taking the drug, technical and supply problems and problems following the drug regimen. Self-reported compliance in this study was high with 69.1% of interviewees stating they never forgot a single dose. 72.2% of interviewees used a reminder method, of which 81.6% were written reminders.
CONCLUSION: This study highlights that although the support systems offered by the paediatric oncology centres were good, certain areas need improvement, specifically the manner in which parents/carers are educated and informed.

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Year:  2008        PMID: 18379895     DOI: 10.1007/s11096-008-9208-5

Source DB:  PubMed          Journal:  Pharm World Sci        ISSN: 0928-1231


  9 in total

1.  Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia.

Authors:  M V Relling; M L Hancock; J M Boyett; C H Pui; W E Evans
Journal:  Blood       Date:  1999-05-01       Impact factor: 22.113

2.  Variable mercaptopurine metabolism in children with leukaemia: a problem of non-compliance?

Authors:  H A Davies; L Lennard; J S Lilleyman
Journal:  BMJ       Date:  1993-05-08

3.  Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia.

Authors:  L Lennard; J S Lilleyman
Journal:  J Clin Oncol       Date:  1989-12       Impact factor: 44.544

Review 4.  Systematic review of randomised trials of interventions to assist patients to follow prescriptions for medications.

Authors:  R B Haynes; K A McKibbon; R Kanani
Journal:  Lancet       Date:  1996-08-10       Impact factor: 79.321

5.  Treatment compliance in childhood and adolescence.

Authors:  C K Tebbi
Journal:  Cancer       Date:  1993-05-15       Impact factor: 6.860

6.  Information and education across the phases of cancer care.

Authors:  M Adams
Journal:  Semin Oncol Nurs       Date:  1991-05       Impact factor: 2.315

7.  Compliance of pediatric and adolescent cancer patients.

Authors:  C K Tebbi; K M Cummings; M A Zevon; L Smith; M Richards; J Mallon
Journal:  Cancer       Date:  1986-09-01       Impact factor: 6.860

8.  A reliable method for evaluating drug compliance in children with cancer.

Authors:  S D Smith; D Rosen; R C Trueworthy; J T Lowman
Journal:  Cancer       Date:  1979-01       Impact factor: 6.860

9.  Risk of relapse in childhood acute lymphoblastic leukemia is related to RBC methotrexate and mercaptopurine metabolites during maintenance chemotherapy. Nordic Society for Pediatric Hematology and Oncology.

Authors:  K Schmiegelow; H Schrøder; G Gustafsson; J Kristinsson; A Glomstein; T Salmi; L Wranne
Journal:  J Clin Oncol       Date:  1995-02       Impact factor: 44.544

  9 in total
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4.  Information Needs Assessment among Parents of Children with Cancer.

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