A L Akinyoola1, O O Adegbehingbe, A O Aboderin. 1. Department of Orthopaedic Surgery and Traumatology, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria. aakinyoola@yahoo.co.uk
Abstract
BACKGROUND: The ideal specimen for identification of the etiologic agents in chronic osteomyelitis for best antibiotic decision remains controversial. OBJECTIVE: To assess the concordance of sinus track culture (STC) with that of intraoperative bone culture (IBC) to guide antibiotic therapy in chronic osteomyelitis. METHODS: A prospective comparative study of chronic osteomyelitis patients seen in our centre from January 2004 to December 2006. Specimens from the depths of sinus track and intraoperative bone biopsy were obtained from each patient and subjected to microbiologic examination and their concordance determined. RESULTS: In STCs Staphylococcus aureus has the highest sensitivity (60.5%), specificity (45.0%) and positive predictive value (72.2%). The overall sensitivity (50.9%), specificity (20%) and predictive value (47.5%) of sinus track specimens were very low. Antibiotic decision based on IBC showed 106 patients (82.8%) had resolution of chronic osteomyelitis at mean of 2 years follow-up. CONCLUSION: IBC appears to predict more reliably the complete etiologic organisms than STCs in chronic osteomyelitis.
BACKGROUND: The ideal specimen for identification of the etiologic agents in chronic osteomyelitis for best antibiotic decision remains controversial. OBJECTIVE: To assess the concordance of sinus track culture (STC) with that of intraoperative bone culture (IBC) to guide antibiotic therapy in chronic osteomyelitis. METHODS: A prospective comparative study of chronic osteomyelitispatients seen in our centre from January 2004 to December 2006. Specimens from the depths of sinus track and intraoperative bone biopsy were obtained from each patient and subjected to microbiologic examination and their concordance determined. RESULTS: In STCs Staphylococcus aureus has the highest sensitivity (60.5%), specificity (45.0%) and positive predictive value (72.2%). The overall sensitivity (50.9%), specificity (20%) and predictive value (47.5%) of sinus track specimens were very low. Antibiotic decision based on IBC showed 106 patients (82.8%) had resolution of chronic osteomyelitis at mean of 2 years follow-up. CONCLUSION:IBC appears to predict more reliably the complete etiologic organisms than STCs in chronic osteomyelitis.
Authors: Luca Maria Sconfienza; Alberto Signore; Victor Cassar-Pullicino; Maria Adriana Cataldo; Olivier Gheysens; Olivier Borens; Andrej Trampuz; Klaus Wörtler; Nicola Petrosillo; Heinz Winkler; Filip M H M Vanhoenacker; Paul C Jutte; Andor W J M Glaudemans Journal: Eur Radiol Date: 2019-06-27 Impact factor: 5.315
Authors: Andor W J M Glaudemans; Paul C Jutte; Maria Adriana Cataldo; Victor Cassar-Pullicino; Olivier Gheysens; Olivier Borens; Andrej Trampuz; Klaus Wörtler; Nicola Petrosillo; Heinz Winkler; Alberto Signore; Luca Maria Sconfienza Journal: Eur J Nucl Med Mol Imaging Date: 2019-01-24 Impact factor: 9.236
Authors: Ashok K Shyam; Parag K Sancheti; Salim K Patel; Steve Rocha; Chetan Pradhan; Atul Patil Journal: Indian J Orthop Date: 2009-10 Impact factor: 1.251