OBJECTIVE: Using an image analysis system to determine whether there is loss of axons in the olfactory tract (OT) in Alzheimer's disease (AD). DESIGN: A retrospective neuropathological study. PATIENTS: Nine control patients and eight clinically and pathologically verified AD cases. MEASUREMENTS AND RESULTS: There was a reduction in axon density in AD compared with control subjects in the central and peripheral regions of the tract. Axonal loss was mainly of axons with smaller (<2.99 microm(2)) myelinated cross-sectional areas. CONCLUSIONS: The data suggest significant degeneration of axons within the OT involving the smaller sized axons. Loss of axons in the OT is likely to be secondary to pathological changes originating within the parahippocampal gyrus rather than to a pathogen spreading into the brain via the olfactory pathways.
OBJECTIVE: Using an image analysis system to determine whether there is loss of axons in the olfactory tract (OT) in Alzheimer's disease (AD). DESIGN: A retrospective neuropathological study. PATIENTS: Nine control patients and eight clinically and pathologically verified AD cases. MEASUREMENTS AND RESULTS: There was a reduction in axon density in AD compared with control subjects in the central and peripheral regions of the tract. Axonal loss was mainly of axons with smaller (<2.99 microm(2)) myelinated cross-sectional areas. CONCLUSIONS: The data suggest significant degeneration of axons within the OT involving the smaller sized axons. Loss of axons in the OT is likely to be secondary to pathological changes originating within the parahippocampal gyrus rather than to a pathogen spreading into the brain via the olfactory pathways.
Authors: Agatha Lyczek; Antje Arnold; Jiangyang Zhang; James T Campanelli; Miroslaw Janowski; Jeff W M Bulte; Piotr Walczak Journal: Exp Neurol Date: 2017-02-02 Impact factor: 5.330