Literature DB >> 18379116

Synthesis of the key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the immunomodulatory agent FTY720 (fingolimod).

Norimasa Matsumoto1, Ryoji Hirose, Shigeo Sasaki, Tetsuro Fujita.   

Abstract

The key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate (13), for the immunomodulatory agent FTY720 (2: fingolimod) was synthesized via Michael addition of diethyl(acetylamino)malonate (6) to 4-octanoylstyrene (12).

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Year:  2008        PMID： 18379116     DOI： 10.1248/cpb.56.595

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  2 in total

1.  Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720.

Authors:  Xuequan Lu; Chaode Sun; William J Valentine; E Shuyu; Jianxiong Liu; Gabor Tigyi; Robert Bittman
Journal:  J Org Chem       Date:  2009-04-17       Impact factor: 4.354

2.  Fingolimod Increases Brain-Derived Neurotrophic Factor Level Secretion from Circulating T Cells of Patients with Multiple Sclerosis.

Authors:  Maya Golan; Karin Mausner-Fainberg; Bassima Ibrahim; Moshe Benhamou; Adi Wilf-Yarkoni; Hadar Kolb; Keren Regev; Arnon Karni
Journal:  CNS Drugs       Date:  2019-12       Impact factor: 5.749
  2 in total

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