Literature DB >> 18378720

Comparison of the essential cellular functions of the two murA genes of Bacillus anthracis.

G C Kedar1, Vickie Brown-Driver, Daniel R Reyes, Mark T Hilgers, Mark A Stidham, Karen Joy Shaw, John Finn, Robert J Haselbeck.   

Abstract

Targeted antisense and gene replacement mutagenesis experiments demonstrate that only the murA1 gene and not the murA2 gene is required for the normal cellular growth of Bacillus anthracis. Antisense-based modulation of murA1 gene expression hypersensitizes cells to the MurA-specific antibiotic fosfomycin despite the normally high resistance of B. anthracis to this drug.

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Year:  2008        PMID： 18378720      PMCID： PMC2415750          DOI： 10.1128/AAC.01594-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

Review 1.  Genomics and antimicrobial drug discovery.

Authors:  D T Moir; K J Shaw; R S Hare; G F Vovis
Journal:  Antimicrob Agents Chemother       Date:  1999-03       Impact factor: 5.191

2.  FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis.

Authors:  M Cao; B A Bernat; Z Wang; R N Armstrong; J D Helmann
Journal:  J Bacteriol       Date:  2001-04       Impact factor: 3.490

3.  Alteration of a single amino acid residue reverses fosfomycin resistance of recombinant MurA from Mycobacterium tuberculosis.

Authors:  Koen A L De Smet; Karen E Kempsell; Alex Gallagher; Ken Duncan; Douglas B Young
Journal:  Microbiology (Reading)       Date:  1999-11       Impact factor: 2.777

4.  Lysine 22 in UDP-N-acetylglucosamine enolpyruvyl transferase from Enterobacter cloacae is crucial for enzymatic activity and the formation of covalent adducts with the substrate phosphoenolpyruvate and the antibiotic fosfomycin.

Authors:  A K Samland; N Amrhein; P Macheroux
Journal:  Biochemistry       Date:  1999-10-05       Impact factor: 3.162

5.  Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin.

Authors:  T Skarzynski; A Mistry; A Wonacott; S E Hutchinson; V A Kelly; K Duncan
Journal:  Structure       Date:  1996-12-15       Impact factor: 5.006

6.  Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.

Authors:  D H Kim; W J Lees; K E Kempsell; W S Lane; K Duncan; C T Walsh
Journal:  Biochemistry       Date:  1996-04-16       Impact factor: 3.162

7.  The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria.

Authors:  Timothy D Read; Scott N Peterson; Nicolas Tourasse; Les W Baillie; Ian T Paulsen; Karen E Nelson; Hervé Tettelin; Derrick E Fouts; Jonathan A Eisen; Steven R Gill; Erik K Holtzapple; Ole Andreas Okstad; Erlendur Helgason; Jennifer Rilstone; Martin Wu; James F Kolonay; Maureen J Beanan; Robert J Dodson; Lauren M Brinkac; Michelle Gwinn; Robert T DeBoy; Ramana Madpu; Sean C Daugherty; A Scott Durkin; Daniel H Haft; William C Nelson; Jeremy D Peterson; Mihai Pop; Hoda M Khouri; Diana Radune; Jonathan L Benton; Yasmin Mahamoud; Lingxia Jiang; Ioana R Hance; Janice F Weidman; Kristi J Berry; Roger D Plaut; Alex M Wolf; Kisha L Watkins; William C Nierman; Alyson Hazen; Robin Cline; Caroline Redmond; Joanne E Thwaite; Owen White; Steven L Salzberg; Brendan Thomason; Arthur M Friedlander; Theresa M Koehler; Philip C Hanna; Anne-Brit Kolstø; Claire M Fraser
Journal:  Nature       Date:  2003-05-01       Impact factor: 49.962

8.  Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes.

Authors:  Daniel R Gentry; Karen A Ingraham; Michael J Stanhope; Stephen Rittenhouse; Richard L Jarvest; Peter J O'Hanlon; James R Brown; David J Holmes
Journal:  Antimicrob Agents Chemother       Date:  2003-06       Impact factor: 5.191

9.  Normally functioning murF is essential for the optimal expression of methicillin resistance in Staphylococcus aureus.

Authors:  R G Sobral; A M Ludovice; S Gardete; K Tabei; H De Lencastre; A Tomasz
Journal:  Microb Drug Resist       Date:  2003       Impact factor: 3.431

10.  Horizontal transfer of drug-resistant aminoacyl-transfer-RNA synthetases of anthrax and Gram-positive pathogens.

Authors:  James R Brown; Daniel Gentry; Julie A Becker; Karen Ingraham; David J Holmes; Michael J Stanhope
Journal:  EMBO Rep       Date:  2003-07       Impact factor: 8.807
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  3 in total

1.  MurAA is required for intrinsic cephalosporin resistance of Enterococcus faecalis.

Authors:  Dušanka Vesić; Christopher J Kristich
Journal:  Antimicrob Agents Chemother       Date:  2012-01-30       Impact factor: 5.191

2.  Novel anion liposome-encapsulated antisense oligonucleotide restores susceptibility of methicillin-resistant Staphylococcus aureus and rescues mice from lethal sepsis by targeting mecA.

Authors:  Jingru Meng; Hui Wang; Zheng Hou; Tao Chen; Jingguo Fu; Xue Ma; Gonghao He; Xiaoyan Xue; Min Jia; Xiaoxing Luo
Journal:  Antimicrob Agents Chemother       Date:  2009-05-11       Impact factor: 5.191

3.  Mechanism of inhibition of Bacillus anthracis spore outgrowth by the lantibiotic nisin.

Authors:  Ian M Gut; Steven R Blanke; Wilfred A van der Donk
Journal:  ACS Chem Biol       Date:  2011-05-05       Impact factor: 5.100
  3 in total

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