| Literature DB >> 18378419 |
Fengying Zhai1, Xiaohong Wang, Dongliu Li, He Zhang, Rui Li, Liansheng Song.
Abstract
We have reported the synthesis and biological evaluation of a decavanadate Na(4)Co(H(2)O)(6)V(10)O(28).18H(2)O (CoV(10)) designed as a potential antitumoral agent. The human cancer cell lines SMMC-7721 (liver cancer) and SK-OV-3 (ovary cancer) were tested for their viability by the MTT method in vitro, which showed that the compound exhibited a remarkable activity against two cell lines with IC(50) values smaller than 0.24 microg/mL, 0.32 microg/mL, respectively. CoV(10) showed the tumor growth suppression for Hep-A-22 (mice liver cancer) in tumor bearing mice in vivo. In addition, using flow cytometry analysis, the ratio of apoptotic cells was up to 8.33% with treatment of CoV(10) at 1.56 microg/mL after 30 min, suggesting that the antitumoral activity of CoV(10) comes from the activation of the apoptotic pathway.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18378419 DOI： 10.1016/j.biopha.2008.01.006
Source DB: PubMed Journal: Biomed Pharmacother ISSN： 0753-3322 Impact factor: 6.529