Literature DB >> 18378339

Impaired transient receptor potential vanilloid 1 in streptozotocin-induced diabetic hearts.

Jun-Xian Song, Li-Hong Wang, Lei Yao, Chao Xu, Zhong-Hai Wei, Liang-Rong Zheng.   

Abstract

Little is known about the effect of diabetes mellitus (DM) on transient receptor potential vanilloid 1 (TRPV1) located in cardiac sensory nerves. This study was performed to test the changes of TRPV1 and its main neuropeptides in diabetic hearts. DM was induced by intraperitoneal injection of streptozotocin (STZ) in C57BL/6J mice. The protein and mRNA expression of TRPV1, calcitonin gene-related peptide (CGRP) and substance P (SP) levels in hearts were measured, respectively. Compared with control mice, blood glucose was significantly increased in diabetic mice (P<0.05), while the protein and mRNA expression of TRPV1, CGRP and SP levels in hearts were essentially reduced in diabetic mice (P<0.05). TRPV1 and its main neuropeptides, CGRP and SP, in hearts were impaired during DM.

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Year:  2008        PMID： 18378339     DOI： 10.1016/j.ijcard.2007.12.081

Source DB:  PubMed          Journal:  Int J Cardiol        ISSN： 0167-5273            Impact factor:   4.164


  9 in total

1.  Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats.

Authors:  Marie Louise M Ghorbani; Chao Qin; Mingyuan Wu; Jay P Farber; Majid Sheykhzade; Bjarne Fjalland; Niels C B Nyborg; Robert D Foreman
Journal:  Auton Neurosci       Date:  2011-09-08       Impact factor: 3.145

2.  Chronic type-I diabetes could not impede the anti-inflammatory and anti-apoptotic effects of combined postconditioning with ischemia and cyclosporine A in myocardial reperfusion injury.

Authors:  Reza Badalzadeh; Ako Azimi; Alireza Alihemmati; Bahman Yousefi
Journal:  J Physiol Biochem       Date:  2016-10-22       Impact factor: 4.158

3.  Electroacupuncture counteracts the development of thermal hyperalgesia and the alteration of nerve growth factor and sensory neuromodulators induced by streptozotocin in adult rats.

Authors:  L Manni; F Florenzano; L Aloe
Journal:  Diabetologia       Date:  2011-03-23       Impact factor: 10.122

Review 4.  Inflammation and neuropeptides: the connection in diabetic wound healing.

Authors:  Leena Pradhan; Christoph Nabzdyk; Nicholas D Andersen; Frank W LoGerfo; Aristidis Veves
Journal:  Expert Rev Mol Med       Date:  2009-01-13       Impact factor: 5.600

Review 5.  Autonomic nerve dysfunction and impaired diabetic wound healing: The role of neuropeptides.

Authors:  Georgios Theocharidis; Aristidis Veves
Journal:  Auton Neurosci       Date:  2019-11-26       Impact factor: 3.145

6.  TRPV1-mediated UCP2 upregulation ameliorates hyperglycemia-induced endothelial dysfunction.

Authors:  Jing Sun; Yunfei Pu; Peijian Wang; Sijiao Chen; Yu Zhao; Chan Liu; Qianhui Shang; Zhiming Zhu; Daoyan Liu
Journal:  Cardiovasc Diabetol       Date:  2013-04-22       Impact factor: 9.951

7.  Calcium activity of upper thoracic dorsal root ganglion neurons in zucker diabetic Fatty rats.

Authors:  Marie Louise Ghorbani; Niels C B Nyborg; Bjarne Fjalland; Majid Sheykhzade
Journal:  Int J Endocrinol       Date:  2013-04-14       Impact factor: 3.257

8.  Substance P enhances the activation of AMPK and cellular lipid accumulation in 3T3‑L1 cells in response to high levels of glucose.

Authors:  Maria Jose Dubon; Yeji Byeon; Ki-Sook Park
Journal:  Mol Med Rep       Date:  2015-10-16       Impact factor: 2.952

9.  Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial Membrane Potential and Myocardial Reperfusion Injury.

Authors:  Carl M Hurt; Yao Lu; Creed M Stary; Honit Piplani; Bryce A Small; Travis J Urban; Nir Qvit; Garrett J Gross; Daria Mochly-Rosen; Eric R Gross
Journal:  J Am Heart Assoc       Date:  2016-09-26       Impact factor: 5.501
  9 in total

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