| Literature DB >> 18377953 |
Rodrigo Jiménez-Jiménez1, María José Cuevas, Mar Almar, Elena Lima, David García-López, José A De Paz, Javier González-Gallego.
Abstract
The present study was aimed to investigate in elderly humans changes in NF-kappaB activation and in the expression of the inflammation-related genes inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and interleukin-6 (IL-6) induced in peripheral blood mononuclear cells (PBMC) by acute eccentric exercise and by submaximal eccentric training. Eleven subjects, aged 66-75 years, carried out 2 bouts of eccentric exercise separated by 8 weeks of training. Following the first bout, NF-kappaB activation, and protein level of p50/p65 subunits, phospho-IkappaBalpha and phospho-IKKalpha increased, while IkappaBalpha protein level was significantly reduced. This was accompanied by a significant increase in iNOS, COX-2 and IL-6 mRNA protein level and protein content. Changes were significantly attenuated following the second exercise bout. In conclusion, acute eccentric exercise increases NF-kappaB activation and the expression of several inflammation-related genes in PBMC from elderly individuals. Regular eccentric training might be an effective method of preventing undesirable inflammatory responses induced by eccentric exercise.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18377953 DOI： 10.1016/j.mad.2008.02.007
Source DB: PubMed Journal: Mech Ageing Dev ISSN： 0047-6374 Impact factor: 5.432