Literature DB >> 18377697

An experimental model for fatal malaria due to TNF-alpha-dependent hepatic damage.

E Seixas1, P Oliveira, J F Moura Nunes, A Coutinho.   

Abstract

While BALB/c mice survive infection with blood stages of Plasmodium chabaudi chabaudi (AS), 70% of DBA/2 mice die by day 9-11 of infection, both strains controlling parasitaemia. We describe here that infection of DBA/2 mice results in extensive, multifocal hepatocyte death. Antibody neutralization of TNF-alpha prevents both liver damage and death.

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Year:  2008        PMID： 18377697     DOI： 10.1017/S0031182008004344

Source DB:  PubMed          Journal:  Parasitology        ISSN： 0031-1820            Impact factor:   3.234


  9 in total

1.  Impact of intravascular hemolysis in malaria on liver dysfunction: involvement of hepatic free heme overload, NF-κB activation, and neutrophil infiltration.

Authors:  Sumanta Dey; Samik Bindu; Manish Goyal; Chinmay Pal; Athar Alam; Mohd Shameel Iqbal; Rahul Kumar; Souvik Sarkar; Uday Bandyopadhyay
Journal:  J Biol Chem       Date:  2012-06-13       Impact factor: 5.157

2.  Heme oxygenase-1 affords protection against noncerebral forms of severe malaria.

Authors:  Elsa Seixas; Raffaella Gozzelino; Angelo Chora; Ana Ferreira; Gabriela Silva; Rasmus Larsen; Sofia Rebelo; Carmen Penido; Neal R Smith; Antonio Coutinho; Miguel P Soares
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-17       Impact factor: 11.205

3.  Networking the host immune response in Plasmodium vivax malaria.

Authors:  Vitor R R Mendonça; Artur T L Queiroz; Fabrício M Lopes; Bruno B Andrade; Manoel Barral-Netto
Journal:  Malar J       Date:  2013-02-21       Impact factor: 2.979

4.  The relevance of non-human primate and rodent malaria models for humans.

Authors:  Jean Langhorne; Pierre Buffet; Mary Galinski; Michael Good; John Harty; Didier Leroy; Maria M Mota; Erica Pasini; Laurent Renia; Eleanor Riley; Monique Stins; Patrick Duffy
Journal:  Malar J       Date:  2011-02-02       Impact factor: 2.979

5.  Behavioural and neurological symptoms accompanied by cellular neuroinflammation in IL-10-deficient mice infected with Plasmodium chabaudi.

Authors:  Kyle D Wilson; Sonja J Stutz; Lorenzo F Ochoa; Gustavo A Valbuena; Petra D Cravens; Kelly T Dineley; Gracie Vargas; Robin Stephens
Journal:  Malar J       Date:  2016-08-24       Impact factor: 2.979

6.  Differential induction of malaria liver pathology in mice infected with Plasmodium chabaudi AS or Plasmodium berghei NK65.

Authors:  Diletta Scaccabarozzi; Katrien Deroost; Yolanda Corbett; Natacha Lays; Paola Corsetto; Fausta Omodeo Salè; Philippe E Van den Steen; Donatella Taramelli
Journal:  Malar J       Date:  2018-01-09       Impact factor: 2.979

7.  The Dynamics of Liver Function Test Abnormalities after Malaria Infection: A Retrospective Observational Study.

Authors:  John Woodford; G Dennis Shanks; Paul Griffin; Stephan Chalon; James S McCarthy
Journal:  Am J Trop Med Hyg       Date:  2018-02-08       Impact factor: 2.345

8.  Augmented particle trapping and attenuated inflammation in the liver by protective vaccination against Plasmodium chabaudi malaria.

Authors:  Jürgen Krücken; Denis Delić; Heike Pauen; Anna Wojtalla; Manal El-Khadragy; Mohamed A Dkhil; Horst Mossmann; Frank Wunderlich
Journal:  Malar J       Date:  2009-04-02       Impact factor: 2.979

9.  Liver Function Test Abnormalities in Experimental and Clinical Plasmodium vivax Infection.

Authors:  Anand Odedra; Lachlan Webb; Louise Marquart; Laurence J Britton; Stephan Chalon; Joerg J Moehrle; Nicholas M Anstey; Timothy William; Matthew J Grigg; David G Lalloo; Bridget E Barber; James S McCarthy
Journal:  Am J Trop Med Hyg       Date:  2020-11       Impact factor: 2.345
  9 in total

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