Natta Rajatanavin1, Suthida Suwanachote, Suthinee Kulkollakarn. 1. Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok 10400, Thailand. ranrj@mahidol.ac.th
Abstract
BACKGROUND: Most treatment protocols for vitiligo usually do not result in complete repigmentation. Therefore, cosmetically acceptable camouflage, low cost and easy to handle alternatives are warranted. OBJECTIVE: To evaluate the efficacy of low-cost self-tanner available in the Thai market in normal subjects with skin types III, IV, and V, and the efficacy for camouflage of 6% dihydroxyacetone (DHA) cream in the treatment of vitiligo on exposed areas of Asian skin. METHODS: The study was divided into two parts. Part 1 is a prospective study of 15 healthy volunteers using three different DHA creams which were available in the Thai market with concentrations of 3.5%, 4.2%, and 5%. Part 2 was a retrospective study of 20 patients suffering from vitiligo affecting the face and/or hands and feet who were treated with 6% DHA. The data were collected through direct examination, telephone interview, face-to-face interview, and photographs. RESULTS: In healthy volunteers, we found that color matching was achieved by using a higher concentration of DHA in darker-skin subjects. Most of the vitiligo patients (88.9%) reported moderate to marked satisfaction with the cosmetic results of 6% DHA cream. CONCLUSION: Dihydroxyacetone offers a safe and effective therapeutic option for recalcitrant vitiligo. Dark-skin subjects need a higher concentration of DHA cream than lighter-skin subjects.
BACKGROUND: Most treatment protocols for vitiligo usually do not result in complete repigmentation. Therefore, cosmetically acceptable camouflage, low cost and easy to handle alternatives are warranted. OBJECTIVE: To evaluate the efficacy of low-cost self-tanner available in the Thai market in normal subjects with skin types III, IV, and V, and the efficacy for camouflage of 6% dihydroxyacetone (DHA) cream in the treatment of vitiligo on exposed areas of Asian skin. METHODS: The study was divided into two parts. Part 1 is a prospective study of 15 healthy volunteers using three different DHA creams which were available in the Thai market with concentrations of 3.5%, 4.2%, and 5%. Part 2 was a retrospective study of 20 patients suffering from vitiligo affecting the face and/or hands and feet who were treated with 6% DHA. The data were collected through direct examination, telephone interview, face-to-face interview, and photographs. RESULTS: In healthy volunteers, we found that color matching was achieved by using a higher concentration of DHA in darker-skin subjects. Most of the vitiligo patients (88.9%) reported moderate to marked satisfaction with the cosmetic results of 6% DHA cream. CONCLUSION:Dihydroxyacetone offers a safe and effective therapeutic option for recalcitrant vitiligo. Dark-skin subjects need a higher concentration of DHA cream than lighter-skin subjects.
Authors: Gabrielle Alves Ribeiro da Silva; Simone Santos de Sousa Oliveira; Sara Fernandes Lima; Rodrigo Pires do Nascimento; Andrea Regina de Souza Baptista; Sorele Batista Fiaux Journal: World J Microbiol Biotechnol Date: 2022-06-11 Impact factor: 4.253