OBJECTIVE: Review of the prevalence of congenital heart defects (CHD) and fetal alcohol spectrum disorder (FASD). DESIGN: We conducted a search of the Medline and Pubmed databases to identify papers reporting the association. We then searched the reference lists of the papers and reference books for additional sources. RESULTS: We found 29 studies that met our inclusion criteria. In the 12 case series studies of subjects with FASD, the proportion of cases with a CHD (atrial [ASD] and ventricular [VSD] septal defects, other defects, or unspecified CHD) ranged from 33% to 100%. From the 14 retrospective studies, the rate of septal defects was 21%, other structural defects 6% and unspecified defects was 12%. For the 2 case-control studies, the odds of CHD ranged from 1.0 (subjects with fetal alcohol effect) to 18.0 (subjects with fetal alcohol syndrome). In the 1 prospective study of CHD the OR for a child to have CHD and FASD was 1.0. KEY CONCLUSION: Pediatric cardiologists may have frequent contact with children with FASD and increased levels of attention to prenatal alcohol exposure as a potential etiology of CHD is indicated.
OBJECTIVE: Review of the prevalence of congenital heart defects (CHD) and fetal alcohol spectrum disorder (FASD). DESIGN: We conducted a search of the Medline and Pubmed databases to identify papers reporting the association. We then searched the reference lists of the papers and reference books for additional sources. RESULTS: We found 29 studies that met our inclusion criteria. In the 12 case series studies of subjects with FASD, the proportion of cases with a CHD (atrial [ASD] and ventricular [VSD] septal defects, other defects, or unspecified CHD) ranged from 33% to 100%. From the 14 retrospective studies, the rate of septal defects was 21%, other structural defects 6% and unspecified defects was 12%. For the 2 case-control studies, the odds of CHD ranged from 1.0 (subjects with fetal alcohol effect) to 18.0 (subjects with fetal alcohol syndrome). In the 1 prospective study of CHD the OR for a child to have CHD and FASD was 1.0. KEY CONCLUSION: Pediatric cardiologists may have frequent contact with children with FASD and increased levels of attention to prenatal alcohol exposure as a potential etiology of CHD is indicated.
Authors: Katie L Davis-Anderson; Hendrik Wesseling; Lara M Siebert; Emilie R Lunde-Young; Vishal D Naik; Hanno Steen; Jayanth Ramadoss Journal: Reprod Toxicol Date: 2018-02-01 Impact factor: 3.143
Authors: Katie L Davis-Anderson; Sebastian Berger; Emilie R Lunde-Young; Vishal D Naik; Heewon Seo; Greg A Johnson; Hanno Steen; Jayanth Ramadoss Journal: Alcohol Clin Exp Res Date: 2017-08-09 Impact factor: 3.455
Authors: Kaviarasan Subramanian; Vishal D Naik; Kunju Sathishkumar; Chandrashekar Yallampalli; George R Saade; Gary D Hankins; Jayanth Ramadoss Journal: Alcohol Clin Exp Res Date: 2014-06-24 Impact factor: 3.455
Authors: Marilene Pavan; Viviane F Ruiz; Fábio A Silva; Tiago J Sobreira; Roberta M Cravo; Michelle Vasconcelos; Lívia P Marques; Sonia M F Mesquita; José E Krieger; Antônio A B Lopes; Paulo S Oliveira; Alexandre C Pereira; José Xavier-Neto Journal: BMC Med Genet Date: 2009-11-03 Impact factor: 2.103