| Literature DB >> 18376867 |
Zhimin Tao1, Matthew P Morrow, Tewodros Asefa, Krishna K Sharma, Cole Duncan, Abhishek Anan, Harvey S Penefsky, Jerry Goodisman, Abdul-Kader Souid.
Abstract
We studied the effect of two types of mesoporous silica nanoparticles, MCM-41 and SBA-15, on mitochondrial O 2 consumption (respiration) in HL-60 (myeloid) cells, Jurkat (lymphoid) cells, and isolated mitochondria. SBA-15 inhibited cellular respiration at 25-500 microg/mL; the inhibition was concentration-dependent and time-dependent. The cellular ATP profile paralleled that of respiration. MCM-41 had no noticeable effect on respiration rate. In cells depleted of metabolic fuels, 50 microg/mL SBA-15 delayed the onset of glucose-supported respiration by 12 min and 200 microg/mL SBA-15 by 34 min; MCM-41 also delayed the onset of glucose-supported respiration. Neither SBA-15 nor MCM-41 affected cellular glutathione. Both nanoparticles inhibited respiration of isolated mitochondria and submitochondrial particles.Entities:
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Year: 2008 PMID： 18376867 DOI： 10.1021/nl080250u
Source DB: PubMed Journal: Nano Lett ISSN： 1530-6984 Impact factor: 11.189